Are you aged 55 to 75 years with no diagnosed chronic illness? Researchers are trialling a dietary supplement rich in antioxidants to promote healthy ageing and you might be able to help!

The Nutraceuticals Research Program at the University of Newcastle are looking for healthy older adults to investigate the health benefits of a dietary supplement rich in antioxidants known as proanthocyanidins derived from Pinus Massoniana (also known as Masson pine).

It is well known that ageing increases susceptibility to various chronic diseases which are mediated through increased inflammation, oxidative stress, muscle wasting, loss of physical function and decline in immune function.

The AGEING WELL Trial will test whether a 50mL elixir containing 1350mg of pinus massoniana consumed daily for 12 weeks will improve markers of oxidative stress, inflammation, blood pressure and support the immune system. Researchers will also examine effects on physical functioning, body composition and overall quality of life.

Who can participate?

Men and women aged 55 to 75 years old with no diagnosed chronic disease such as type 2 diabetes, cancer, arthritis.

This study may not be suitable for people taking certain medications such as anti-inflammatories or anti-coagulants (e.g. warfarin or aspirin) or regularly consuming certain supplements such as fish oils. Individuals who smoke or consume more than 10 standard alcohol drinks per week will also be ineligible to participate.

Why is the research being done?

Adequate nutritional intake and regular physical activity are long known preventative strategies for combating age-associated chronic disease risk. Dietary supplements may complement or enhance these strategies and improve quality of life. Pinus Massoniana is a rich source of polyphenols called proanthocyanidins which are known to have antioxidant, anti-inflammatory, and immune-modulating effects.

What would you be asked to do?

If you agree to participate and you meet the eligibility criteria, you will be asked to do the following:

  1. Come to the Nutraceuticals Research Program Clinical Trial Facility at the University of Newcastle for 3 visits over the 12-week period. Parking permits will be provided for all visits. During these appointments, you will be asked to bring completed questionnaires on your dietary intake, physical activity levels and medical history; have your blood pressure checked and blood collected, and undergo basic physical function tests (approx. 1.5 hours).
  2. Attend the Newcastle Bone Density Centre for 3 visits over the 12-week period for a body x-ray scan to measure body composition including bone density (approx 10-15 minutes).

You will be asked to fast overnight for all visits.

  1. Consume every day as part of your regular diet and lifestyle 50mL elixir containing either 1350mg pinus massoniana or placebo (identical elixir with no active ingredients). There is a 50% chance of being in the active group and neither you nor the researchers will know whether you’re receiving the pinus massoniana or placebo.  

Click here to download the Participant Information Sheet

Researchers: Professor Manohar Garg, Dr Jessica Ferguson, Dr David Bentley

To find out more or to register your interest please contact Dr Jessica Ferguson on (02) 4921 5636 or

This study has been approved by the Human Research Ethics Committee (H-2020-0271) and is supported by Tismor Health & Wellness.