We will examine how PHDi drives cytokine signalling in immune cells obtained from blood and tissue of healthy individuals and IBD patients. Feasibility for this work has been demonstrated in murine models. Our studies will determine the biological relevance of HIF-mediated anti-inflammatory signalling as a potential therapeutic strategy for IBD inflammation in patients.
Researchers
Dr Simon Keely, Dr Ellen Marks, Associate Professor Marin Veysey
Research Area
Project type
Project Grant
Year of funding
2014