Inflammatory Bowel Disease (IBD) is the umbrella term for a group of chronic gastrointestinal diseases which include Crohn’s (CD) and ulcerative colitis (UC), affecting over 70,000 Australians, for which there is no cure.

We will examine how PHDi drives cytokine signalling in immune cells obtained from blood and tissue of healthy individuals and IBD patients. Feasibility for this work has been demonstrated in murine models. Our studies will determine the biological relevance of HIF-mediated anti-inflammatory signalling as a potential therapeutic strategy for IBD inflammation in patients.

Researchers 

Dr Simon Keely, Dr Ellen Marks, Associate Professor Marin Veysey

Project type 
Project Grant
Year of funding 
2014