Dementia and cogitive decline are major concerns for our ageing population. Cholesterol is a promminent risk factor for Alzheimer's Disease. If a person has a particular form of the cholesterol carrying protein Apolipoprotein E (ApoE) their chances of developing Alzheimer's Disease rise 15 fold.

This grant will profile how the major cell types of the brain process cholesterol and other lipids at different ages across the adult life span - providing the first accurate picture of how ageing effects how the brain handles cholesterol.

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