Eosinophilic Oesophagitis in childhood is associated with chronic heartburn, nausea, vomiting, dysphagia, failure to thrive, food getting stuck in the oesophagus and can result in permanent scarring of the oesophagus. Delays in diagnosis and treatment failure is not uncommon. There is no cure, and no predictor for treatment response has been identified.

Current first-line treatment is the introduction of restrictive diets that are difficult to maintain and require multiple rounds of anaesthesia to conduct the tests to identify the optimal approach for each patient.

We will use tissue from each patient routinely collected at the initial diagnosis to target the intervention approach to the specific allergen responsible for the condition for each individual patient. This truly personalised approach holds the promise to greatly simplify the dietary adjustment required to treat the disease and reduce the number of times these children will require anaesthesia and endoscopies.

 

Researchers 
Project type 
Project Grant
Year of funding 
2019