This project will use an innovative laboratory model to identify new targets for the treatment of Colorectal cancer. This work is particularly focused on the role of tissue oxygen in health and disease. Tissue oxygen deficit (hypoxia) is a hallmark feature of colorectal tumours. This work will invetigate the role of a low oxygen -sensing protein in tumour growth, in driving cancer cell metastasis and its effect on the colorectal cancer microbiome.
Colorectal cancer (CRC) remains amongst the most commonly diagnosed type of cancer in Australia and world-wide.