p53 can control estrogen responses, and loss of this control is associated with poorer outcome in breast cancer. Loss of p53 function by a genetic fault occurs in far less breast cancers than expected, given its essential role in stopping cancer growth. This suggests that its function becomes disrupted in other ways to promote breast cancer. Additionally, smaller forms of p53 have been discovered that can inhibit its function.
This study will investigate whether these small forms of p53 can alter estrogen responses and p53 function and, in turn, promote development of breast cancer. This will provide new insights into how p53 loses its function in breast cancer, and may identify new targets for its prevention and treatment.