Our Role & Impact

Enabling the discoveries that ensure families are happy and healthy

Our Role & Impact
  1. Our Role & Impact
  2. RESEARCH PROJECTS FUNDED THROUGH HMRI
  3. Receptor tyrosine kinase mutations in acute myeloid leukaemia promote PP2A and p53 inhibition through the phosphorylation of SBDS

Receptor tyrosine kinase mutations in acute myeloid leukaemia promote PP2A and p53 inhibition through the phosphorylation of SBDS

AML (acute myeloid leukemia) is a very aggressive form of leukemia. Tumour suppressor proteins are critically important for normal healthy cells to be protected from genetic mutations. However in AML mutations occur in the genes responsible for stem growth and cell differentiation.

The growth of the blood stem cells is accelerated but their differentiation into other cells is inhibited. This grant will investigate the consequences of altered tumour suppressor cellular signaling mechanisms in AML with the hope that these studies will lead to tailored treatment regimens in order to improve clinical outcomes into the future.

Researchers 

Dr Matt Dun, Dr Nicole M Verrills

Research Area 
Cancer
Project type 
Project Grant
Year of funding 
2016