The growth of the blood stem cells is accelerated but their differentiation into other cells is inhibited. This grant will investigate the consequences of altered tumour suppressor cellular signaling mechanisms in AML with the hope that these studies will lead to tailored treatment regimens in order to improve clinical outcomes into the future.
AML (acute myeloid leukemia) is a very aggressive form of leukemia. Tumour suppressor proteins are critically important for normal healthy cells to be protected from genetic mutations. However in AML mutations occur in the genes responsible for stem growth and cell differentiation.