It has recently been recognised that many stroke patients can experience what is known as ‘chronic phase decline” associated with gradual, but very significant, declines in both motor and cognitive function.

In many cases late phase declines will only begin to manifest themselves in the months following stroke, long after a patient has been discharged into the community. Late phase declines appear to be driven, at least in part, by a process referred to a secondary neurodegeneration and is worsened by high levels of psychological stress. This study will determine if blocking the major stress hormone (cortisol) can limit the negative effects that high levels of stress have on secondary neurodegeneration, and to what extent does this improve late phase declines in those that have suffered from stroke?


Associate Professor Frederick Rohan Walker, Dr Lin Ong, Dr Ming Yang, Associate Professor Sarah Johnson

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