The exact cause of premature ovarian failure remains unknown. Often the problem is present from birth but can also develop later post-puberty. Premature ovarian failure impacts on fertiltiy, but also has implications for lifelong health, including increased rates of osteoporosis. This project will unravel the complex cellular signalling pathways altered when a woman experiences premature ovarian failure.
Premature ovarian failure (POF) is the early loss of ovarian function before age 40.