The Breast Cancer Translational Research Laboratory J.C. Heuson based at Institut Bordet, in Brussels, uses several molecular approaches to gain a better understanding of breast tumorigenesis, metastasis, and drug resistance.
Fluoropyrimidines (5-FU and capecitabine) are anticancer drugs commonly used in a range of cancers including oesophageal, gastric and colorectal cancers. Their toxicity is unpredictable, leading to significant and sometimes life-threatening side effects. Pharmacokinetics (steady state plasma level, area under the curve, etc.) varies between patients by a factor of 5-10, and this is also unpredictable. Although therapeutic drug monitoring might allow better management of pharmacokinetic variability by rapid dose adjustment, it is labour-intensive and time-consuming.
Stroke is the leading cause of long-term disability in Australia and the second leading cause of death.
