Category: News & Articles
... to injury – what is the molecular connection between tissue damage and organ failure,” Professor Zsolt Balogh, Director of Trauma ... inflammation – it is the naturally occurring mitochondrial DNA within cells. Professor Balogh likens them to a Trojan horse: ... happily inside but when the cells die due to trauma the mitochondrial DNA leaks out,” he said. “It actually looks like bacterial DNA and, ...
Category: General
By inhibiting a key player in the DNA repair pathway we could improve the effectiveness of ... known as reactive oxygen species (ROS). This ROS further damages the DNA of the leukaemia cells, inducing more errors in the gene sequences of the cell. If this damage is not repaired properly the leukaemia cells acquire additional ...
Category: Research
... known as reactive oxygen species (ROS). This ROS further damages the DNA of the leukaemia cells, inducing more errors in the gene sequences of the cell. If this damage is not repaired properly the leukaemia cells acquire additional ... ROS. These patients display over-activation of an error-prone DNA repair pathway. We have discovered that in FLT3 mutant patients a ...
Category: Research
... called XPC that detects when chemotherapy has damaged the cell’s DNA. We have some preliminary data indicating that XPC is not in the ... and Prof Sue Clark (Garvan Institute) Research Investigation of DNA repair and the epigenome in chemoresistant high grade serous ovarian ...
Category: Research
... a defined function in our body. Cancer develops when one cell suffers damage to its DNA. Our DNA contains all of our genes. DNA can undergo multiple types of damage ...
Category: Researcher Profiles
... responded to their chemotherapy Investigating how UV-light damages DNA and causes melanomas to develop. If we know how UV causes a melanoma ... because of it. Brief Profile Associate Professor Nikola Bowden is the DNA Repair Group Leader and a Cancer Institute NSW Career Development ... The DNA repair team is working towards using old chemotherapies to damage the DNA of tumours just enough that the patient’s immune system ...
Category: Researcher Profiles
... industries respectively. Research Interests Oxidative stress and DNA damage in spermatozoa Assisted reproductive technologies ... Semen assessment Flow cytometry Lange animal handling and management DNA damage assays Affiliations PRC in Reproductive Science Society ...
Category: General
... quality control mechanisms used by the egg and early embryo to ensure DNA quality. Specifically, my work focused on the protective strategies afforded by efflux transporter proteins, DNA Repair pathways and the contribution of novel pro-survival factors ... Development Embryo Development Assisted Reproductive Technologies DNA Damage Placental Development Implantation Failure Miscarriage and Early ...
Category: General
... quality control mechanisms used by the egg and early embryo to ensure DNA quality. Specifically, my work focused on the protective strategies afforded by efflux transporter proteins, DNA Repair pathways and the contribution of novel pro-survival factors ... Development Embryo Development Assisted Reproductive Technologies DNA Damage Placental Development Implantation Failure Miscarriage and Early ...
Category: Researcher Profiles
... and potentially alter reproductive health including oxidative stress (damage caused by reactive oxygen species) and DNA damage. Laureate Professor Aitken has also developed several commercial ...
