BUST-BP-Dose Study

Researchers at the Hunter Medical Research Institute (HMRI) are looking at the effects of reducing long periods of sitting, with regular activity breaks, to improve blood pressure in those who have had a stroke.

The BUST-BP-Dose study will monitor blood pressure and blood sugar levels in people who have had a stroke between 3 months and 10 years ago. The study will look at the amount of short activity breaks needed to improve blood pressure in stroke survivors and reduce their risk of having another stroke.

The study is being supported by a Heart Foundation Vanguard Grant, Hunter Medical Research Institute research support grant and Priority Research Centre for Stroke and Brain Injury research support grant.

Register your interest

To find out more or to register your interest please contact Dr Gary Crowfoot on 02 40420759 (Gary.Crowfoot@newcastle.edu.au) or Mr Paul Mackie on 0420881472 (Paul.I.Mackie@uon.edu.au).

Who can participate in the research?
  • People who have had a stroke between 3 months and 10 years ago, and
  • People who can walk without physical help
Why is the research being done?

Research has shown that people who have had a stroke spend long periods of the day sitting – more than people who haven’t had a stroke. Spending long periods of time sitting is known to increase the risk of disease, such as cardiovascular disease or diabetes. Stroke survivors from the Hunter helped us show that breaking up sitting time with activity breaks improves blood pressure in people who have had a stroke.

This new study wants to find out how much more activity breaks are needed to see greater improvements in blood pressure, and improve blood sugar levels.  

Results from this pilot study will help to inform future larger scale trials to see how breaking up sitting time at home can improve the health of people with stroke.

What would you be asked to do?

Participants will be asked to come to HMRI 4 times, with about 1 week between visits. The research team can organise and pay for a taxi for you if you can’t drive to us. You may be seen by one or more of the following researchers:

Your visits will be in the following order:

  1. Visit 1 (Familiarisation visit) – 2.5 hours.

We will ask you to:

  • Give us some information about your stroke and general health
  • Have your blood pressure taken
  • Do a walk test over 10 metres
  • Talk to a dietitian about what you usually eat
  1. Visit 2 (Baseline condition) – 8 hours

We will ask you to:

  • Sit in a comfortable lounge chair for 8 hours (toilet breaks allowed & food provided!)

We will:

  • Take a measure of your blood pressure every 30 minutes
  • Take small blood samples every 30-60 minutes. We will put an intravenous line (like a ‘drip’) in your arm at the beginning of the day and use this to collect the blood samples.
  1. Visit 3 (Activity breaks) – 8 hours

This will be the same as visit 2, but we will also ask you to do some simple exercises whilst standing a few times a day

  1. Visit 4 (More activity breaks) – 8 hours

This will be the same as visit 3, but we will ask you to do a few more of the standing exercises through the day.

You will be provided with a meal to eat the night before visits 2, 3 and 4.

Participant information statements

If you are comfortable reading documents yourself, click here to download participant information statement

If you have someone who helps you with reading documents, click here to download person responsible participant information statement

Register your interest

To find out more or to register your interest please contact Dr Gary Crowfoot on 02 404 20759 (Gary.Crowfoot@newcastle.edu.au) or Mr Paul Mackie on 0420881472 (Paul.I.Mackie@uon.edu.au).

Hunter Stroke Research Register

This study is also inviting people from the Hunter Stroke Research Volunteer Register to participate. To be invited to participate in other studies in stroke rehabilitation and recovery, register here.