Cardiovascular Health

People who are 'at risk' of type 2 diabetes, or have pre diabetes, or have type 2 diabetes comprise a significant proportion of the Australian population and this health issue in increasing at a very significant rate.

Phase I of this study will investigate feasibility and efficacy of a self-help, gender-tailored weight loss program for male workers with or without the provision of additional program components targeting stress and mental health  (SHED-IT only vs. SHED-IT plus SHED-IT: Recharge).

This project will undertake preliminary work to inform future grants and development of a personalised web-platform that supports pregnant women to optimise their dietary intakes. If a woman’s diet is compromised in pregnancy, evidence from the developmental origins of health and disease hypothesis indicates the foetus is programmed for a greater lifetime risk of chronic disease. Currently pregnant women are not routinely given advice on how to eat optimally as a way to give infants the best start to life. It is left to chance or the woman seeking information herself. This is a missed opportunity. 

Migraines are headaches so severe that the World Health Organisation regards them as a form of temporary disability. A throbbing, often unilateral headache lasts from several hours to days and may be accompanied by nausea or a combination of photophobia and phonophobia. In ~20% of cases it is preceded by an aura. Estimated to afflict 15% of Australians, migraines vary considerably in characteristics but are identifiable by internationally classified criteria. The causes of migraine are thought to include both cerebrovascular and neuronal mechanisms to which individuals are genetically or hormonally predisposed. Women are 2-3 times as susceptible as men, particularly during menstruation and perimenopausally, when migraine without aura may result from sudden changes in circulating estrogen, other hormones or prostaglandins. Hormone replacement therapy or phytoestrogen supplementation may help in some cases, although the evidence is weak and mechanisms are unclear. 

Owing to better therapies, patients with type 1 diabetes (T1D) are living longer and are now a unique population that has been little studied. Differing from type 2 diabetes (T2D), the onset of T1D is usually juvenile, but it is increasingly diagnosed in adulthood, requiring immediate insulin therapy. Regardless, T1D and T2D share a common sequelae of blood vessel damage and accelerated cognitive decline. Even children and adolescents with T1D display early declines in executive function and short-term working memory and impaired growth and plasticity of brain tissues, thereby compromising learning in school.

The left atrium (LA) is one of the four chambers of the heart. Its primary roles are to act as a holding chamber for blood returning from the lungs and to act as a pump to transport blood to the left ventricle of the heart, after which the blood flows to the body.

The Gene Pulser Xcell system is a modular electroporation system for transfecting every cell type.

Dexmedetomidine is an intravenous sedative drug with increasing clinical use anaesthesia and intensive care. The drug acts within the central nervous system (CNS) and has potential adverse effects on the control of breathing and the circulation.

This project will focus on providing telehealth nutrition intervention for rural parents who are concerned about their child’s weight or eating habits.

This grant will support our eHealth research project measuring the impact of web-based feedback on dietary intake in improving eating patterns and health.

Fathers have a unique and key role in shaping their children's dietary and physical activity behaviors and emerging evidence suggests suboptimal physical activity and dietary behaviours of fathers may be passed on to their children at a very young age.

Following a cardiovascular event (e.g. heart attack) the heart undergoes significant physical changes, including an increase in scar tissue, changes in morphology and decreased functional capacity (heart remodelling).

Tracy, a member of HMRI's Cardiovascular Research Program,  aspires not only be a leading researcher but also a research leader and was recently named a 2016 NSW Young Tall Poppy of the Year. Tracy will use the Equal Futures funding to access one on one leadership mentoring with the Institute of Executive Coaching and leadership.

Heart failure is one of the most costly health problems worldwide. A hallmark of heart failure is cardiac fibrosis, an abnormal and persistent accumulation of scar tissue (mainly the extracellular matrix protein, collagen) that significantly impairs heart function.

$10K to support our eHealth research project measuring the impact of web-based feedback on dietary intake in improving eating patterns and health. We have a trial approved through ethics, but no $$ to test the impact on dietary intake, hence this will fund this pilot study.
 

Dopamine and droperidol are drugs used in modern anaesthetic practice. Both drugs are known to modulate carotid body function via an action on dopamine type-2 receptors. 

We have identified a novel protein in the aging heart, fibulin3. 

Funding to  IMCAS is devoted to education in the field of cosmetic dermatology, cosmetic surgery and cosmeceuticals.

The aim of my PhD is to investigate effective and innovative approaches to managing weight during pregnancy and following childbirth.

Engaging dads and daughters to increase physical activity and social and emotional well-being in pre-adolescent girls. 

40% of all type 2 diabetics will develop diabetic nephropathy (DN), which is the leading cause of end stage kidney failure in Australia and around the world.

Considerable evidence exists supporting the health benefits of youth engaging in regular physical activity yet physical inactivity in adolescence remains widespread.

Following a heart attack, a large proportion of the heart muscle is replaced by scar tissue. This results in a weaker heart and the clinical syndrome of heart failure. There is currently no treatment for scar tissue in the heart.

Engaging dads and daughters to increase physical activity and social and emotional well-being in pre-adolescent girls

Children whose parents suffer a heart attack or stroke prematurely are at a particularly high risk, inheriting a predisposition to heart disease as well as their parent’s eating habits and lifestyle behaviours.

Type 2 Diabetes is the fastest growing chronic disease in Australia.

Diet and Cardiovascular disease risk

Children’s screen-time is high. The time that young people spend sedentary, especially the time they spend alone watching television and using computers, is a major public health issue.

Digestive disorders remain a major health burden.

Young women are vulnerable to weight gain, which places them at risk of weight related co-morbidities, such as depression, infertility and Type 2 Diabetes. 

In 2008-09, a rigorous, randomised controlled trial of the Healthy Dad, Healthy Kids (HDHK) program was conducted at the University of Newcastle.

There has been considerable research into the use of exercise for the treatment of depression in adults, however the majority of research in adolescent major depressive disorder (MDD) over the past decade has focused on the efficacy of medications and cognitive behaviour therapy (CBT), with these methods only achieving rates of remission of 30% to 40% and high rates of relapse among those responding positively (Kennard et al., 2006).