Information Based Medicine

With over 3 billion pairs of amino acids in the human genome, it is no wonder that computer science and mathematical modelling have converged with biology to generate the revolutionary field of information based medicine.

Information based medicine is often referred to as bioinformatics, or the use of computer science and mathematical modelling to interpret extremely large amounts of biological data.

By embracing the interdisciplinary nature of the challenge that is personalised medicine, the diverse team of researchers in the HMRI information based medicine group are paving the way for an increasingly patient-tailored approach to healthcare.

Due to the lengthy and complicated nature of genetic sequences, this research method is commonly applied to the field of genetics and cancer genetics to yield specific and personal disease information from complex genetic data.

The two research arms of the HMRI information based medicine research group are the bioinformatics group and the medical genetics group led by Professor Pablo Moscato and Professor Rodney Scott respectively.

Professor Pablo Moscato | Personalised Medicine and Data Analytics
Research Program :
  • Information Based Medicine
Research Topics :
Bioinformatics, Brain Cancer, Breast Cancer, Neuroscience
Professor Rodney Scott
Research Program :
  • Information Based Medicine
Research Topics :
Breast Cancer, Medical Genetics, Ovarian & Endometrial Cancer, Pancreatic, Colorectal & Rare Cancers, Schizophrenia
Research Program :
  • Information Based Medicine
Research Topics :
Bioinformatics
Research Program :
  • Information Based Medicine
Research Topics :
Medical Genetics, Neuroscience, Psychology
Associate Professor Yuqing Lin
Research Program :
  • Information Based Medicine
Research Topics :
Bioinformatics
Dr Vicki Maltby
Research Program :
  • Information Based Medicine
Research Topics :
Medical Genetics

2015

Analyses of epigenetic signatures of post-mortem lesions in MS brains and correlation to circulating body fluids
Scholarship
Researchers:

Conjoint Associate Professor Jeannette Lechner-Scott, Katherine Sanders, Rebecca Seeto
 

Description:

Every cell and process in you body is coded by the same genetic material. For a body to function normally, signals must be sent around the body instructing particular geners to switch on or off. 

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Development of a chemotherapy test for ovarian cancer
Project Grant
Researchers:

Dr Nikola Bowden, Dr Jim Scurry, Dr Geoff Otton, Dr Ken Jaaback, Dr Janine Lombard
 

Description:

To develop a test for predicting ovarian cancer response/resistance to cisplatin chemotherapy that can be quickly implemented in clincial centres.

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The effect of treatment on patients with Multiple Sclerosis
Project Grant
Description:

Multiple Sclerosis (MS) is the most common non-traumatic neurological disorder that affects young adults.

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The Virtuous Circle: A Living Brain Cancer BioBank
Project Grant
Researchers:

Professor Rodney Scott, Dr Craig Gedye

Description:

Whilst treatments for brain cancer are improving these do not work well in all patients. 

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Analyses of epigenetic signatures of post-mortem lesions in MS brains and correlation to circulating body fluids
Scholarship
Researchers:

C A/Prof Jeannette Lechner-Scott, Katherine Sanders, Rebecca Seeto

Description:

MS is a chronic, life-long, disease which has no cure.

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Development of a chemotherapy response/resistance test for ovarian cancer
Project Grant
Researchers:
Description:

Ovarian cancer is usually treated with a chemotherapy drug called cisplatin which works by damaging DNA so much that the tumour cells die. 

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Small p53 isoforms, BIG implications for treatment response in breast cancer
Project Grant
Researchers:

Dr Kelly Avery-Kiejda, Professor Rodney Scott

Description:

Breast cancer is the most common cancer in women, with 1 in 9 women diagnosed in their lifetime.

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2014

MicroRNA’s of the Brain and Blood in Multiple Sclerosis
Project Grant
Description:

This project aims to confirm or refute the predicted targets of the deregulated miRNA and determine the functional impact this has on cellular behaviour in the MS brain.

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Karen Brown Breast Cancer Research Travel Grant
Travel Grant
Researchers:
Description:

The 65th Annual Meeting of the American Society of Human Genetics (ASHG) 2015, Baltimore, MD, USA (6-10 October 2015)
 

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Computational prediction and functional clarification of novel drug combination strategies for the treatment of brain tumours
Project Grant
Characterization of non-genetic factors causing Multiple Sclerosis.
Project Grant
Description:

MS is progressive, unpredictable and varies extensively between individuals. 

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A new frontier in breast cancer: Can small molecules in the blood predict outcome?
Project Grant
Researchers:
Description:

The research team has identified 27 small molecules called micro RNAs that are associated with very aggressive triple negative breast cancer subtype.

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The Virtuous Circle: A Living Brain Cancer BioBank
Project Grant
Researchers:

Professor Rodney Scott, Dr Craig Gedye 

Description:

Whilst treatments for brain cancer are improving these do not work well in all patients.

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An Investigation on the Consensus Between Different Genomic and Transcriptomic Results in Breast Cancer
Travel Grant
Researchers:

Ms Heloisa Milioli, Pablo Moscato, Jennette Sakoff 

Description:

The Breast Cancer Translational Research Laboratory J.C. Heuson based at Institut Bordet, in Brussels, uses several molecular approaches to gain a better understanding of breast tumorigenesis, metastasis, and drug resistance.

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Development of a chemotherapy response/resistance test for ovarian cancer
Project Grant
Researchers:
Description:

Ovarian cancer is usually treated with a chemotherapy drug called cisplatin which works by damaging DNA so much that the tumour cells die.

more
Towards an early detection of clinical symptoms of Alzheimer's disease
Project Grant
Description:

Pablo specialises in a cutting edge research field known as "Personalised Information Based Medicine".

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Small p53 isoforms, BIG implications for treatment response in breast cancer
Project Grant
Researchers:

Dr Kelly Avery-Kiejda, Professor Rodney Scott 

Description:

Breast cancer is the most common cancer in women, with 1 in 9 women diagnosed in their lifetime. Estrogen and an important gene known to stop cancer development (p53) are essential for normal breast growth. 

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p53 isoforms in breast cancer - MM Sawyer Estate Scholarship
Scholarship
Researchers:

Brianna Morten, Professor Rodney Scott, Dr Kelly Avery -Kiejda

Description:

Estrogen and p53 (a gene known to stop cancer development) are essential in normal breast growth.

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2013

Targeted next-generation sequencing of potential breast cancer susceptibility genes (Bridge Funding)
Fellowship
Description:

Michelle’s PhD project is entitled The Contribution of Genetic Susceptibility to Breast Cancer. 

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Antipituitary Autoantibodies and Pituitary Target Autoantigens
Project Grant
Researchers:

Dr Vicki Maltby, Associate Professor Patricia Crock, Professor Rodney Scott

Description:

The thyroid gland is responsible for the secretion of hormones involved in growth, sleep patterns, and cognitive development.

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Happy Healthy Children: A genome wide association study on childhood brain tumours
Project Grant
Researchers:

Professor Rodney Scott, Dr Frank Alvaro, Tiffany-Jane Evans, Elizabeth Milne, Bruce Armstrong, Professor John Attia, Elizabeth Holliday 

Description:

Brain tumours are the second most frequent cancer diagnosed in children yet very little is known about the risk factors associated with their occurrence or what events are necessary for their progression.

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Development of a chemotherapy response/resistance test for ovarian cancer
Project Grant
Researchers:
Description:

Ovarian cancer is usually treated with a chemotherapy drug called cisplatin which works by damaging DNA so much that the tumour cells die.

more
Towards an early detection of clinical symptoms of Alzheimer's disease
Project Grant
Description:

In Australia, Alzheimer’s disease is huge health burden, with one person diagnosed with Alzheimer’s disease every 6 minutes. Symptoms of dementia are often noticed by family members three years before an official diagnosis.

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miRNA regulation of growth, invasion and treatment response in triple negative breast cancer
Project Grant
Researchers:

Dr Kelly Avery-Kiejda, Ms Andrea Mathe, Professor Rodney Scott 

Description:

Breast cancer is the most common malignancy that develops in women, responsible for the highest cancer-related death rates. While the prognosis is good if the cancer is limited to the breast; once a patient has developed metastatic disease they are essentially incurable.

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Drugs that act on the renin-angiotensin system; repositioning their therapeutic targets to endometrial cancer
Project Grant
A genome-wide study of lymphocyte-specific DNA methylation status in relation to Multiple Sclerosis
Project Grant
Description:

To identify the major lymphocyte-specific epigenetic loci associated with susceptibility to MS

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The function of the delta-40p53 isoform in breast cancer
Project Grant
Researchers:

Dr Kelly Avery-Kiejda, Brianna Morten, Rodney Scott 

Description:

Breast cancer is the most common cancer that develops in women. A gene known to suppress cancer development (p53) is essential for the normal growth of the breast. Loss of this control is associated with poor outcome in breast cancer.

more
p53 isoforms in breast cancer
Scholarship
Researchers:

Brianna Morten, Professor Rodney Scott, Dr Kelly Avery-Kiejda 

Description:

Estrogen and p53 (a gene known to stop cancer development) are essential in normal breast growth.

more

2012

HCRF Travel Award 2012
Travel Grant
Researchers:
MicroRNA in Multiple Sclerosis
Project Grant
Rotary Club of Cardiff Melanoma Scholar Award
Scholarship
Researchers:
Develop a genetic test for diagnosis of childhood skin cancer and neurological disorders
Project Grant
Researchers:
Small p53 isoforms, BIG implications for treatment response in breast cancer
Project Grant
Researchers:

Dr Kelly Avery-Kiejda, Professor Rodney Scott
 

2011

HMRI Travel PhD Student Conference Prize
Project Grant
Researchers:
p53 isoforms in breast cancer - MM Sawyer Estate Scholarship
Scholarship
Researchers:

Brianna Morten, Professor Rodney Scott, Dr Kelly Avery-Kiejda
 

The cytokine gene expression profile in multiple sclerosis patients with chronic fatigue - Mark Smith Multiple Sclerosis Research Project Grant
Project Grant
Researchers:

Dr Karen Ribbons, Dr Jeannette Lechner-Scott
 

PULSE Education Prize
Project Grant
Researchers:

Dr Natalie Beveridge
 

PULSE Education Prize
Project Grant
Researchers:

Daniel Johnstone

Mark Hall PhD Student Conference Prize
Project Grant
Researchers:

Amy Martin

Development of a diagnostic genetic test for childhood skin cancer disorders - Lawrie Bequest Paediatric Oncology Research Project Grant
Project Grant
Researchers:

2010

Research Higher Degree support grant in Medical Innovation - Genetic Variation in Breast Cancer
Project Grant
Researchers:
MicroRNA in Multiple Sclerosis
Project Grant
Nucleotide excision repair gene expression in melanoma
Project Grant
Researchers:

Dr Nikola Bowden, Katie Ashton, Stephen Braye, Rodney Scott, Ricardo Vilain

p53 isoforms, a prognostic indicator in breast cancer?
Project Grant
Researchers:

Dr Kelly Avery-Kiejda, Rodney Scott, John Forbes 

Pulse Education Prize
Project Grant
Researchers:

Dr Katie Ashton 

The identification of microRNAs as therapeutic targets for the treatment of advanced breast cancer
Project Grant
Researchers:

Dr Kelly Avery Kiejda, Professor Rodney Scott 

Identification of novel biomarkers for pre-clinical Alzheimer's disease
Project Grant
Researchers:

Associate Professor Pablo Moscato, Liz Milward, Martin Gomez Reavetti, Daniel Johnstone, Gillies Guillemin, Regina Barretta 

Genetic influences in colorectal cancer: a global consortium
Project Grant
Researchers:
Gene expression profiling of Xeroderma pigmentosum 1 yr fellowship
Fellowship
Researchers:

2009

Genome wide SNP association study of childhood acute lymphoblastic leukaemia.
Project Grant
Search for modifer genes influencing breast cancer incidence in families diagnosed with hereditary nonpolyposis colorectal cancer.
Project Grant
PULSE Education Prize
Project Grant

2008

PhD Scholarship
Scholarship
PULSE Research Exchange
Project Grant
Researchers:

Mr Mathew Cox
 

Genome wide SNP association study of childhood acute lymphoblastic leukaemia
Project Grant
Identification of novel markers in paediatric acute lymphoblastic leukaemia; investigation of DNA methylations and non-coding small microRNAs
Project Grant
Researchers:

Dr Kyu-Tae Kim, Professor Rodney Scott
 

Post Doctoral Fellowship - Gene expression profiling of Xeroderma pigmentosum - post doctoral fellowship - 1 year - Katie Ashton
Fellowship
Researchers:
Award for Research Excellence - Rodney Scott
HMRI Award for Research Excellence
Researchers:

2007

Gene expression profiling of xeroderma pigmentosum
Project Grant
Researchers:
PULSE Education Prize
Project Grant
Researchers:
Identification of a predictive approach to assigning to undefined xeroderma pigmentosum patients to subgroups using gene expression profiling
Project Grant
Researchers:
NBN Children's Cancer Research scholarship x 3 (part of NBN Fellowship funds) Bente Talseth, David Mossman, Stuart Reeves
Scholarship
Researchers:

Professor Rodney ScottBente Talseth, David Mossman, Stuart Reeves

2006

Computational methods for breast cancer genetic profiling using genome-wide data
Project Grant
Researchers:

Dr Alexandre Mendes
 

Genetic susceptibility in endometrial cancer (supporting a PhD student to undertake part of their thesis work in a collaborating laboratory outside Newcastle (cost code P671-6007)
Project Grant
Researchers:

Dr Katie Ashton
 

Genetic origins of childhood cancer
Project Grant
Health and wellbeing of partners of victims of trauma; a vulnerable group in the community
Project Grant
Researchers:

Dr Tracey Dudding, Professor Gillian Turner
 

NBN Children's Cancer Research scholarship x 3 (part of NBN Fellowship funds) Bente Talseth, David Mossman, Stuart Reeves
Scholarship
Researchers:

Professor Rodney ScottBente Talseth, David Mossman, Stuart Reeves

2005

NBN Children's Cancer Research scholarship x 3 (part of NBN Fellowship funds) Bente Talseth, David Mossman, Stuart Reeves
Scholarship
Researchers:

Professor Rodney ScottBente Talseth, David Mossman, Stuart Reeves

NBN Children's Cancer Research scholarship x 3 (part of NBN Fellowship funds) Bente Talseth, David Mossman, Stuart Reeves
Equipment Grant
Researchers:
NBN Children's Cancer Research scholarship x 3 (part of NBN Fellowship funds) Bente Talseth, David Mossman, Stuart Reeves
Fellowship
Researchers:
Acute Stroke - Imaging the Ischaemic Penumbra with Perfusion CT
Project Grant
Researchers:
Donation for research into Haemochromatosis
Project Grant
Researchers:

Ms Adrianne Milward
 

Award for Outstanding Achievement in Cancer Research
Project Grant
Researchers:

2004

Anaemia mini-nutritional assessment pilot survey in conjunction with assessment of symptoms
Project Grant
Researchers:

Ms Adrianne Milward
 

The role of MYHgene mutations in persons who have developed early onset colorectal cancer.
Project Grant
Researchers:

2003

Evaluating a new genetic risk factor for hereditary colon cancer
Project Grant
Researchers:

2002

The genetic origins of childhood cancer
Project Grant