Professor Andrew Boyle

Research Program:
Research Topics:
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2017 Project Grant
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2016 Project Grant
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2015 Project Grant
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2014 Project Grant
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2014 Project Grant

What are your research interests?

I am interested in cardiovascular health - in particular why people are suffering heart attacks at such a young age. The second part of my research is the regeneration of heart muscle following heart attacks and heart failure. We are looking at stem cell therapy to replace damaged tissue in the heart with viable, functional muscle. It's in the clinic that research questions pop into my mind, which then drives the experimental research in the laboratory. We are also conducting clinical trials on drug treatments and surgical interventions for cardiac patients.

Why did you get into research?

My passion for research was ignited when I saw too many young people in the clinic struck down by heart attacks, with those who survive often suffering with heart failure or weakness of the heart muscle. Heart attacks are so wasteful and so tragic for the patients’ families, and as a clinician I was drawn to both that acute side of cardiovascular research and also the chronic medical aspects surrounding the long-term weakness of the heart muscle after such an attack. 

What would be the ultimate goal for your research?

My vision for my research is better cardiac health in the Hunter region and reversing the damage caused by prior heart attacks to promote long and healthy lives for patients. 

Biography

Professor Andrew Boyle is a clinically trained cardiologist and respected leader in cardiovascular research. He has a keen interest in the reparative processes in the heart after damage and how to reverse scaring and tissue damage after heart attacks. 

After completing his PhD in cardiac regeneration at the University of Melbourne and a prestigious postdoctoral position at Johns Hopkins University in the US, he then studied the effects of ageing on the ability of the heart to pump oxygenated blood to the rest of the body (left ventricular remodeling).

Professor Boyle now leads a successful research laboratory based at HMRI where he studies pre-clinical models of left ventricular remodeling, and is also an active clinician and clinical researcher at the John Hunter Hospital working to improve the outcomes of people affected by heart attacks and heart muscle damage. 

In the laboratory, Professor Boyle and his team study several important aspects of heart function and heart remodeling after damage. He is currently investigating the potential for stem cells to repair the human heart after events like a heart attack and believes that this avenue of research holds promising results for the future treatment of patients. 

He is also involved in a number of clinical trials that aim to find new drug treatments for people affected by cardiovascular disease and also to develop new heart valves for implantation in patients. 

Professor Boyle is a Fellow of the Society for Cardiac Angiography and Intervention, the American Heart Association, the American College of Cardiology, a Professor and also the Head of the Cardiovascular Medicine Disciple at the University of Newcastle. He has published over 80 peer reviewed scientific articles and has presented at numerous national and international conferences around the world. 

Specialised / Technical Skills

  • Cardiology
  • cardiac regeneration
  • left ventricular remodeling
  • cardiac fibrosis
  • stem cell therapy
  • cardiac catheterisation 
  • cardiac haemodynamic measurements
  • coronary angioplasty and stenting
  • transcatheter aortic valve replacement (TAVR)

Affiliations

  • HMRI Program: Cardiovascular
  • Subgroup: Clinical Cardiovascular
  • Department of Cardiovascular Medicine, John Hunter Hospital.
  • Department of Cardiology, Lake Macquarie Private Hospital.
  • National Heart Foundation NSW Cardiovascular Research Network: Management Team member
  • American Heart Association: Fellow
  • American College of Cardiology: Fellow
  • Society for Cardiovascular Angiography and Interventions: Fellow

2018

Characterising the role of Fibulin-3 in health and disease
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Description:

Cardiovascular Disease is the leading cause of death worldwide and the Hunter Region has one of the highest rates of heart disease in Australia.

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Fibulin-3 and Cardiac Fibrosis
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Researchers:
Description:

Heart failure is one of the most costly health problems worldwide. A hallmark of heart failure is cardiac fibrosis, an abnormal and persistent accumulation of scar tissue (mainly the extracellular matrix protein, collagen) that significantly impairs heart function.

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Fibulin-3 and Cardiac Fibrosis
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2017

Fibulin-3 and Cardiac Fibrosis
Project Grant
Researchers:
Characterising the role of Fibulin-3 in health and disease
Project Grant
Description:

Cardiovascular Disease is the leading cause of death worldwide and the Hunter Region has one of the highest rates of heart disease in Australia.

more
Fibulin-3 and Cardiac Fibrosis
Project Grant
Researchers:
Description:

Heart failure is one of the most costly health problems worldwide. A hallmark of heart failure is cardiac fibrosis, an abnormal and persistent accumulation of scar tissue (mainly the extracellular matrix protein, collagen) that significantly impairs heart function.

more

2016

Fibulin-3 and Cardiac Fibrosis
Project Grant
Researchers:
Characterising the role of Fibulin-3 in health and disease
Project Grant
Description:

Cardiovascular Disease is the leading cause of death worldwide and the Hunter Region has one of the highest rates of heart disease in Australia. Recently the research team has identified a new protein called fibulin-3 which is expressed in the ageing heart.

more
Fibulin-3 and Cardiac Fibrosis
Project Grant
Researchers:
Description:

Heart failure is one of the most costly health problems worldwide. A hallmark of heart failure is cardiac fibrosis, an abnormal and persistent accumulation of scar tissue (mainly the extracellular matrix protein, collagen) that significantly impairs heart function.

more

2015

Knockout model for heart fibrosis
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Researchers:
Description:

We have identified a novel protein in the aging heart, fibulin3. 

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Fibulin-3 and Cardiac Fibrosis
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2014

Fibulin-3 and Cardiac Fibrosis
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Development of a novel model of cardiac scar tissue
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Researchers:
Description:

Following a heart attack, a large proportion of the heart muscle is replaced by scar tissue. This results in a weaker heart and the clinical syndrome of heart failure. There is currently no treatment for scar tissue in the heart.

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