Funding for clinical trial coordinator for MIDAS2
Dr Heidi Janssen
Funding for clinical trial coordinator for MIDAS2
Associate Professor Brett Graham, Dr Phil Jobling, Ms Kelly Smith
Changes to the nervous system during chronic pain remain poorly understood. What we do know is that nerve cells in the spinal cord play an important role in pain signalling because the spinal cord is the first site where information from our bodies is processed to ultimately shape sensory experience.
Stroke can be devastating - often leaving a person disabled or deceased. This Stroke Finder Helmet is an innovative tool which could have enormous impact for survival and disability rates for stroke victims.
A/Prof Suzanne Snodgrass, Mr Rutger de Zoete
Neil Spratt, Dr Damian McLeod
Ischaemic stroke, caused by blood clot blocking an artery to the brain, is a leading cause of death and disability. In around 10% of patients the stroke enlarges in the first 24-48 h (stroke-in-progression). Typically, these are people who arrive with mild or rapidly improving stroke symptoms, but most end up with long-term disability. There is no effective treatment, in part because for the last few decades we have been wrong about the cause for stroke progression, so have been trying to treat the wrong mechanism.
Adrian Dunlop, Dr Amanda Brown, Dr Chris Dayas, A/Prof Peter Stanwell.
Stroke Finder Helmet Part 1 - Acute Care of Stroke Patients
Parkinson’s disease is the second most common neurodegenerative disorder, with 6.3 million people diagnosed worldwide; 80,000 of these are Australian. This means that around one out of every 350 Australians suffers from this life changing debilitating disease. Parkinson’s disease appears more frequently in males than females. The majority of Parkinson’s disease cases are idiopathic- of unknown cause. Parkinson’s disease is characterised by degeneration in the dopaminergic neurons in the substantia nigra (a structure in the midbrain). The dopaminergic neurons are nerve cells that make and contain a neurotransmitter known as dopamine. Oxidative stress and neuroinflammation are thought to be involved in degeneration of the dopaminergic neurons.
The unmet needs of carers of stroke survivors.
The 470,000 Australians living with stroke are at high risk of developing cognitive deficits and vascular dementia. There are currently no generally accepted therapeutic interventions for improving cognition post-stroke.
Balance is essential for every aspect of daily life and especially important for activities that people of the Hunter region are known to enjoy, including surfing, cycling, and running. A complete or partial loss of balance, or vestibular dysfunction, can be catastrophic for the individual and community.
Special grant for Josh Atkins to travel to France to speak at a conference and then go on to make some important collaborations in both France and UK in bioinformatics and personalised medicine.
Co-sponsorship for Dr Terri Armstrong to speak at 11th COGNO Scientific Meeting in Brisbane 7-9 October 2018.
Dr Nikola Bowden, Dr Andre van der Westhuizen
To overcome treatment resistance in melanoma there needs to be i) decrease in the amount of disease and ii) re-establishment of tumour recognition by the immune system.
AML (acute myeloid leukemia) is a very aggressive form of leukemia. Tumour suppressor proteins are critically important for normal healthy cells to be protected from genetic mutations. However in AML mutations occur in the genes responsible for stem growth and cell differentiation. The growth of the blood stem cells is accelerated but their differentiation into other cells is inhibited.
Dr Mike Fay
Understanding and overcoming treatment resistance in brain tumours
The Role of Tumour Microenvironment in Ovarian Cancer
Currently the major hurdle facing the successful treatment of solid cancers is the development of metastases (tumour spread), and our lack of understanding of what controls this process.
Cancer is the most common cause of childhood disease-related deaths, with leukaemia the most common childhood cancer in Australia.
Treatment for the most common and deadly form of blood cancer (acute myeloid leukaemia) hasn’t changed in over 40 years. New treatments fail because leukaemia’s genes have a high propensity to mutate, causing rapid resistance to therapies. We have discovered that these gene mutations cause chemical-modifications to the cells defence systems. Unrestrained growth of these cancerous cells results in the production of excess reactive by-products that progressively change the cancer, making long-term treatment response and patient survival unlikely. This project will test whether targeting these chemical-modifications will be a more effective new treatment strategy.
Neuro Oncology is a niche area with around 500 newly diagnosed GLioma patients per year in NSW; however the care and support needs for this patient group are great, with high carer burden.
Dr Anthony Proietto
The CN2 will provide expert clinical consultancy to support high level care coordination for brain cancer patients requiring complex management.
Dr Matt Dun, Dr Nikki Verrills
By inhibiting a key player in the DNA repair pathway we could improve the effectiveness of chemotherapeutic treatments.
Half of all malignant childhood gliomas arise in the brainstem, most frequently in the ventral pons as diffuse intrinsic pontine gliomas (DIPG). The anatomical location of the tumour precludes surgical resection, leaving only radiotherapy as the established therapy. Unfortunately, radiotherapy is only temporarily beneficial, and occasionally completely fails, leaving patients without treatment option.
Prof Clare Collins, Dr Lee Ashton
This project will undertake preliminary work to inform future grants and development of a personalised web-platform that supports pregnant women to optimise their dietary intakes. If a woman’s diet is compromised in pregnancy, evidence from the developmental origins of health and disease hypothesis indicates the foetus is programmed for a greater lifetime risk of chronic disease. Currently pregnant women are not routinely given advice on how to eat optimally as a way to give infants the best start to life. It is left to chance or the woman seeking information herself. This is a missed opportunity.
This three year phase of the Dads and Daughter Exercising and Empowered (DADEE) project aims to transition the DADEE program to a sustainable model embedded in the Newcastle community, capitalising on the achievements of the initial 2014-2016 grant period.
Cardiovascular Disease is the leading cause of death worldwide and the Hunter Region has one of the highest rates of heart disease in Australia.
Anthony Quail, David Cottee
Dexmedetomidine is an intravenous sedative drug with increasing clinical use anaesthesia and intensive care. The drug acts within the central nervous system (CNS) and has potential adverse effects on the control of breathing and the circulation.
This project will focus on providing telehealth nutrition intervention for rural parents who are concerned about their child’s weight or eating habits.
Heart failure is one of the most costly health problems worldwide. A hallmark of heart failure is cardiac fibrosis, an abnormal and persistent accumulation of scar tissue (mainly the extracellular matrix protein, collagen) that significantly impairs heart function.
The left atrium (LA) is one of the four chambers of the heart. Its primary roles are to act as a holding chamber for blood returning from the lungs and to act as a pump to transport blood to the left ventricle of the heart, after which the blood flows to the body.
To be used as a conference travel award for a late-stage PhD student or and Early Career Researcher, researching in the fields of physical activity or exercise science.
People who are 'at risk' of type 2 diabetes, or have pre diabetes, or have type 2 diabetes comprise a significant proportion of the Australian population and this health issue in increasing at a very significant rate.
Coronary artery disease (CAD) remains one of the leading causes of mortality and morbidity worldwide. Despite the optimal use of anti-anginal medications and coronary revascularization, a large number of patients with CAD suffer from severe symptoms with disabling angina and heart failure.
There has been considerable research into the use of exercise for the treatment of depression in adults, however the majority of research in adolescent major depressive disorder (MDD) over the past decade has focused on the efficacy of medications and cognitive behaviour therapy (CBT), with these methods only achieving rates of remission of 30% to 40% and high rates of relapse among those responding positively (Kennard et al., 2006).
The role of extracellular matrix protein 1 (ECM1) in cardiac fibrosis.
Physical inactivity has been described as a global pandemic, as it is one of the leading causes of death and disability in Australia and globally. It is directly linked to chronic conditions including obesity, Type 2 diabetes, heart disease, depression, and some cancers.
Ovarian cancer is usually treated with a chemotherapy drug called cisplatin which works by damaging DNA so much that the tumour cells die. Cisplatin is used to treat a wide variety of tumours in addition to ovarian cancer including, testicular, head and neck and non-small cell lung cancer. In addition, it forms the basis of most combined treatment regimes (where 2 or more drugs are used in combination). The downside to cisplatin is that it is extremely toxic and although some patients benefit substantially from treatment, a large proportion suffer the toxic side effects without any therapeutic benefit. We are aiming to develop a personal test to determine if cisplatin is likely to be effective for an individual’s ovarian cancer, so that the toxic side effects can be avoided if the drug is not going to work.
Breast cancer is the most common cancer in women, with 1 in 9 women diagnosed in their lifetime
Conjoint A/Prof Bruce King, Dr Carmel Smart
Type 1 diabetes (T1D) is the fastest growing chronic disease affecting Australian children. T1D is a lifelong condition where the body is not able to produce insulin which controls blood glucose. People with T1D must follow a strict daily regime of blood glucose testing, insulin administration and careful dietary management to control their blood glucose levels. Good blood glucose control is critically important in preventing life- threatening complications of diabetes.
This proposal seeks funding to establish a Targeted Nanoparticle Development Facility within the Hunter Medical Research Institute. We also seek funding for a post-doctoral scientist who will use the technology to develop novel diagnostics that will identify cancer metastases from thyroid and ovarian cancers, locate other endocrine cancers and importantly develop new ways of treating ovarian and thyroid cancer through improved delivery of existing chemotherapy drugs.
The Provider will implement the ‘Gomeroi Gayaanggal’ Project to provide a holistic approach to social and emotional wellbeing within the Indigenous communities of Tamworth and Walgett, and will add Taree and Forster in Stage 2.
Globally, nearly 1% of all pregnancies end in stillbirth (3 million each year). The magnitude and gravity of stillbirth is such that in 2011 an entire Lancet series was devoted to it and urged a strong call to action, concluding that greater knowledge of causes is a key health priority. In Australia, stillbirth accounts for around 70% of all perinatal deaths (7 deaths per day) and is nearly 40 times more common than Sudden Infant Death Syndrome. Existing knowledge has had no impact on reducing the stillbirth rate, and a 2013 BMJ review of the UK data on stillbirth concluded ""preventive strategies need to focus on improving antenatal detection."
Bruce King, Graham Goodwin
Funding to support the Gomeroi gaaynggal Community ArtsHealth running in Tamworth - covers art consumables which brings participants into the centre to participate in health screening and research being conducted.
A/Prof Bruce King
The New South Wales tablelands are a known region to have low environmental iodine in soil. This is similar to other regions around the world such as the Himalayas and Papua New Guinea. This is known to impact the food grown locally. The introduction of iodised salt into diets has assisted in reducing the impact. However, modern diets with a reliance on processed foods that are not required to use iodised salt, has left "modern diets" deficient in iodine.
Laureate Professor Roger Smith AM, Mrs Lee Dedman
Travel funding to Wellington NZ to learn 3D animation 13/4/2018-25/4/2018
Can miners at risk of long-term low back pain be identified and provided with a low back pain prevention intervention to prevent the development of persistant pain co-existing lifestyle health risks?
Despite innovative programs to increase colorectal cancer (CRC) screening amongst people >50 years of age, such the National Bowel Cancer Screening Program (NBCSP), current screening rates are low.
I am an Early Career Researcher with a passion for improving the health of children, specifically through nutrition school-based policies and practices. My PhD project focused on the development of a scalable policy implementation support program for a state-based school healthy eating strategy.
Ms Georgia Carroll, Dr Simon Keely, Dr Peter Pockney
Colorectal cancer (CRC) is the commonest cancer that affects both men and women in Australia. Approximately one third of patients diagnosed with the disease die from it within five years of diagnosis. Most of these deaths occur from metastatic disease. Many of these cancers develop in patients who had no apparent metastatic disease when they were first treated with what is intended to be curative resection.
Smoking leads to lung inflammation that causes emphysema - a major health problem in Australia. Emphysema progressively declines even if smoking stops and there are no treatments. Recently changes in gut microbes have been linked to inducing or protecting against inflammation in the gut and lung. Thus we may be able to control inflammation by modifying these gut microbiomes. We may be able to ingest specific microbes or use specific antibiotics or other factors as new treatments for emphysema.
Asthma is a common condition that causes tightness in the chest, coughing and wheeze and makes it difficult to breath. Around 10.2% of the Australian population (approximately 2.3 million people) have asthma, it is a major health problem here in Australia and worldwide.
Investigating the genetics of the development of lung cancer.
Bronchoconstriction is a cardinal feature of asthma, generating mechanical stresses within the airways including cell compression and increased shear stress due to increased air-flow.
Asthma is a common and often disabling chronic disease that makes breathing difficult. Approximately 3 million Australians have asthma – 10% of the population. Asthma causes significant lifetime disability, has a high disease burden, and caused 455 deaths in Australia in 2016. Estimated direct and indirect costs to the Australian Government and businesses are $24.7 billion due to health care costs, productivity loss, reduced quality of life and premature death (Deloitte Access Economics, “Hidden Costs of Asthma”, 2015). Much of this burden comes from people with severe asthma who do not have control of their asthma symptoms despite high-dose treatment. Severe asthma is the focus of my research.
Kidney stones affect approximately 9% of the population, with rates increasing globally. Whilst the surgical techniques used to remove obstructive stones have improved, few if any advances have been made to prevent stone recurrence. Stones are a significant risk factor for the development of chronic kidney disease, which currently affects 2 million Australians.
Currently there is a two year wait list to see an Ear Nose & Throat (ENT) specialist in the Hunter New England district, the largest health district in NSW with one ENT specialist clinic. Lack of access to specialist health care creates a significant disparity in health outcomes for Indigenous and rural patients. Serious health complications, including deafness lead to socioeconomic disadvantage.
Develop, implement and evaluate an evidence based education program for paramedics, related telehealth technologies and a model of care which enables "Advanced Out of Hospital Care".
Using computer vision to match the faces of children with undiagnosed intellectual disability.