Brain and Mental Health Research
Brain and Mental Health Research
Brain & Mental Health

Service change and Supporting Lifestyle and Activity Modification after TIA (S+SLAM-TIA)
Project Grant
Researchers:
Description:

S+SLAM-TIA is a research project evaluating the effect of translation of an evidence based stroke prevention education and exercise program into the Hunter New England Local Health District (HNE LHD) health service.

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Novel Mechanisms of ‘Stroke-in-Progression’: Intracranial pressure elevation and collateral blood vessel failure after minor stroke
Project Grant
Researchers:

Neil Spratt, Dr Damian McLeod

Description:

Ischaemic stroke, caused by blood clot blocking an artery to the brain, is a leading cause of death and disability. In around 10% of patients the stroke enlarges in the first 24-48 h (stroke-in-progression). Typically, these are people who arrive with mild or rapidly improving stroke symptoms, but most end up with long-term disability. There is no effective treatment, in part because for the last few decades we have been wrong about the cause for stroke progression, so have been trying to treat the wrong mechanism.

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Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Researchers:
Description:

The unmet needs of carers of stroke survivors.

 

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Growth hormone to promote brain recovery after stroke
Project Grant
Researchers:
Description:

The 470,000 Australians living with stroke are at high risk of developing cognitive deficits and vascular dementia. There are currently no generally accepted therapeutic interventions for improving cognition post-stroke.

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Jennie Thomas Medical Research Travel Grant
Travel Grant
Researchers:

Lauren Poppi

Description:

Balance is essential for every aspect of daily life and especially important for activities that people of the Hunter region are known to enjoy, including surfing, cycling, and running. A complete or partial loss of balance, or vestibular dysfunction, can be catastrophic for the individual and community.

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Sports Concussion Clinic
Project Grant
Researchers:
Jennie Thomas Travel Grant
Travel Grant
Researchers:

Joshua Atkins

Description:

Special grant for Josh Atkins to travel to France to speak at a conference and then go on to make some important collaborations in both France and UK in bioinformatics and personalised medicine.

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11th COGNO Scientific Meeting
Travel Grant
Researchers:

Catherine Hidson

Description:

Co-sponsorship for Dr Terri Armstrong to speak at 11th COGNO Scientific Meeting in Brisbane 7-9 October 2018.

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Cancer Research
Cancer Research
Cancer

Predicting tOxicity for Myeloma Therapy (PrOMT)
Project Grant
Researchers:
Description:

Multiple myeloma (MM) is a cancer of plasma cells, which are mature white blood cells within the bone marrow. The disease causes bone pain, fractures, infections, anaemia and renal failure. It typically affects people over the age of 60, with about 1700 new diagnoses each year in Australia.[1] It is incurable and carries a life expectancy of 2-7 years depending on the aggressiveness of the tumour cells.

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Haematology Research
Project Grant
Researchers:

Dr Anoop Enjeti, Ms Nadine Berry

Development of a chemotherapy response/resistance test for ovarian cancer
Project Grant
Description:

Ovarian cancer is usually treated with a chemotherapy drug called cisplatin which works by damaging DNA so much that the tumour cells die. Cisplatin is used to treat a wide variety of tumours in addition to ovarian cancer including, testicular, head and neck and non-small cell lung cancer. In addition, it forms the basis of most combined treatment regimes (where 2 or more drugs are used in combination). The downside to cisplatin is that it is extremely toxic and although some patients benefit substantially from treatment, a large proportion suffer the toxic side effects without any therapeutic benefit. We are aiming to develop a personal test to determine if cisplatin is likely to be effective for an individual’s ovarian cancer, so that the toxic side effects can be avoided if the drug is not going to work.

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Tetraspanin CD9; more than just an exosome marker - A novel biomarker to target for prostate cancer
Project Grant
Description:

Currently the major hurdle facing the successful treatment of solid cancers is the development of metastases (tumour spread), and our lack of understanding of what controls this process.

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Developing new treatments for resistance in acute myeloid leukaemia
Project Grant
Researchers:
Description:

Treatment for the most common and deadly form of blood cancer (acute myeloid leukaemia) hasn’t changed in over 40 years. New treatments fail because leukaemia’s genes have a high propensity to mutate, causing rapid resistance to therapies. We have discovered that these gene mutations cause chemical-modifications to the cells defence systems. Unrestrained growth of these cancerous cells results in the production of excess reactive by-products that progressively change the cancer, making long-term treatment response and patient survival unlikely. This project will test whether targeting these chemical-modifications will be a more effective new treatment strategy.

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Neuro Oncology Networking Meeting for Nurses and Allied Health
Travel Grant
Researchers:

Marina Kastelan

Description:

Neuro Oncology is a niche area with around 500 newly diagnosed GLioma patients per year in NSW; however the care and support needs for this patient group are great, with high carer burden. 

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MHF Brain Cancer Care Coordinator
Project Grant
Researchers:

Dr Anthony Proietto

Description:

The CN2 will provide expert clinical consultancy to support high level care coordination for brain cancer patients requiring complex management.

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Targeting DNA repair for the improved treatment of blood cancers
Project Grant
Researchers:

Dr Matt Dun, Dr Nikki Verrills

Description:

By inhibiting a key player in the DNA repair pathway we could improve the effectiveness of chemotherapeutic treatments.

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Early detection and monitoring of DIPG
Project Grant
Researchers:
Description:

Half of all malignant childhood gliomas arise in the brainstem, most frequently in the ventral pons as diffuse intrinsic pontine gliomas (DIPG). The anatomical location of the tumour precludes surgical resection, leaving only radiotherapy as the established therapy. Unfortunately, radiotherapy is only temporarily beneficial, and occasionally completely fails, leaving patients without treatment option.

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Cardiovascular Research
Cardiovascular Research
Cardiovascular

Characterising the role of Fibulin-3 in health and disease
Project Grant
Description:

Cardiovascular Disease is the leading cause of death worldwide and the Hunter Region has one of the highest rates of heart disease in Australia.

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The feasibility and preliminary efficacy of referral to exercise physiologists, psychologists, and supplementary physical behaviour change strategies for school teachers 'at risk' for Type 2 Diabetes
Project Grant
Researchers:

Professor Ronald Plotnikoff, Wendy Brown, Kerry Courneya, Ronald Sigal, Associate Professor Erica James, Professor David Lubans, Kristen Cohen

Description:

People who are 'at risk' of type 2 diabetes, or have pre diabetes, or have type 2 diabetes comprise a significant proportion of the Australian population and this health issue in increasing at a very significant rate.

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Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Researchers:

Sean Hardy

Description:

The role of extracellular matrix protein 1 (ECM1) in cardiac fibrosis.

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Jennie Thomas Medical Research Travel Grant
Travel Grant
Researchers:

Sarah Kennedy

Description:

Physical inactivity has been described as a global pandemic, as it is one of the leading causes of death and disability in Australia and globally. It is directly linked to chronic conditions including obesity, Type 2 diabetes, heart disease, depression, and some cancers.

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Pregnancy & Reproduction Research
Pregnancy & Reproduction Research
Pregnancy & Reproduction

Is placental aging the key to understanding, predicting and preventing stillbirth?
Fellowship
Researchers:
Description:

Globally, nearly 1% of all pregnancies end in stillbirth (3 million each year). The magnitude and gravity of stillbirth is such that in 2011 an entire Lancet series was devoted to it and urged a strong call to action, concluding that greater knowledge of causes is a key health priority. In Australia, stillbirth accounts for around 70% of all perinatal deaths (7 deaths per day) and is nearly 40 times more common than Sudden Infant Death Syndrome. Existing knowledge has had no impact on reducing the stillbirth rate, and a 2013 BMJ review of the UK data on stillbirth concluded ""preventive strategies need to focus on improving antenatal detection."

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Australian Artificial Pancreas Program
Project Grant
Researchers:

Bruce King, Graham Goodwin

Gomeroi gaaynggal Community ArtsHealth
Project Grant
Researchers:
Description:

Funding to support the Gomeroi gaaynggal Community ArtsHealth running in Tamworth - covers art consumables which brings participants into the centre to participate in health screening and research being conducted.

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The prediction and prevention of hypoglycaemia using insulin suspension in a randomised controlled trial (PLGM study)
Project Grant
Researchers:

A/Prof Bruce King

Helping to Close the Gap by determining the prevalence of iodine deficiency and related thyroid and goitre health problems
Project Grant
Researchers:

Patrick Oakley

Description:

The New South Wales tablelands are a known region to have low environmental iodine in soil. This is similar to other regions around the world such as the Himalayas and Papua New Guinea. This is known to impact the food grown locally. The introduction of iodised salt into diets has assisted in reducing the impact. However, modern diets with a reliance on processed foods that are not required to use iodised salt, has left "modern diets" deficient in iodine.

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Stillbirth video production - travel grant
Travel Grant
Researchers:
Description:

Travel funding to Wellington NZ to learn 3D animation 13/4/2018-25/4/2018

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Haggarty Foundation HMRI Research Fellowship in Stillbirth
Fellowship

Public Health Research
Public Health Research
Public Health

An online intervention to improve child dietary intake in childcare.
Project Grant
Researchers:

Alice Grady

Description:

Internationally, 41 million children aged 0-5 years were overweight or obese in 2016(1). Poor nutrition is one of the most important risk factors for the development of obesity(2). As early childhood is a formative time for developing healthy eating behaviours, population health strategies that support children to eat better are of upmost importance(3).

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Understanding the link between immune cell function and lung function in the development of asthma in early life
Project Grant
Researchers:
Description:

Asthma affects one in eight children in Australia and is the leading cause of hospitalisations and emergency visits, with an estimated annual health care cost of more than 24 billion Australian dollars in 2015. Asthma is the most common medical complication in pregnancy and is strongly associated with the development of childhood asthma. ntion strategy for asthma.

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Improving uptake of colorectal cancer screening among primary care attendees
Scholarship
Researchers:
Description:

Despite innovative programs to increase colorectal cancer (CRC) screening amongst people >50 years of age, such the National Bowel Cancer Screening Program (NBCSP), current screening rates are low.

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Award for Early Career Research - Serene Yoong
HMRI Award for Early Career Research
Researchers:
Award for Research Excellence - Jennifer Martin
HMRI Award for Research Excellence
Jennie Thomas Medical Research Travel Grant
Travel Grant
Researchers:

Kathryn Reilly

Description:

I am an Early Career Researcher with a passion for improving the health of children, specifically through nutrition school-based policies and practices. My PhD project focused on the development of a scalable policy implementation support program for a state-based school healthy eating strategy.

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Viruses, Infections / Immunity, Vaccines & Asthma
Viruses, Infections / Immunity, Vaccines & Asthma
Viruses, Infections / Immunity, Vaccines & Asthma

Mini-organs in a dish: a personalised test for cystic fibrosis treatment to reduce the need for lung transplantation
Project Grant
Researchers:
Description:

Cystic Fibrosis (CF) is the most common life threatening genetic condition in Australia and affects many organs, in particular the lungs, and is one of the 3 most common reasons for a lung transplant. Although improved treatments have seen life expectancy extended, the average life expectancy of a CF patient in Australia is still only 38.

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Understanding how cohabiting bacteria in urine influence treatment of urinary infections and urinary leakage in children: a pilot study
Project Grant
Researchers:
Description:

Urinary leakage in the daytime, feeling of urgency to urinate and frequent urination are common and often incapacitating problems in school-aged children. If affects 5-10% of healthy, otherwise normal children and significantly disrupts their day-to-day life and learning.(6,7)  This has consequences for mental health and healthy development.

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Investigation of the role of mechanical forces in respiratory disease
Project Grant
Investigating the role of microbiomes in COPD
Project Grant
Researchers:
Description:

Smoking leads to lung inflammation that causes emphysema - a major health problem in Australia. Emphysema progressively declines even if smoking stops and there are no treatments. Recently changes in gut microbes have been linked to inducing or protecting against inflammation in the gut and lung. Thus we may be able to control inflammation by modifying these gut microbiomes. We may be able to ingest specific microbes or use specific antibiotics or other factors as new treatments for emphysema.

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Award for Mid Career Research - Lisa Wood
HMRI Award for Mid Career Research
Researchers:
Patient Reported Outcome Measure in Severe Asthma (PROMISe): Measuring Severe Asthma’s Impact on Health Status
Project Grant
Description:

Asthma is a common condition that causes tightness in the chest, coughing and wheeze and makes it difficult to breath. Around 10.2% of the Australian population (approximately 2.3 million people) have asthma, it is a major health problem here in Australia and worldwide.

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Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Researchers:

Vrushali Chimankar

Description:

Investigating the genetics of the development of lung cancer.

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The role of apical mechanical shear stress on epithelial cell function in asthma
Project Grant
Researchers:
Description:

Bronchoconstriction is a cardinal feature of asthma, generating mechanical stresses within the airways including cell compression and increased shear stress due to increased air-flow.

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Jennie Thomas Medical Research Travel Grant
Travel Grant
Researchers:
Description:

Asthma is a common and often disabling chronic disease that makes breathing difficult. Approximately 3 million Australians have asthma – 10% of the population. Asthma causes significant lifetime disability, has a high disease burden, and caused 455 deaths in Australia in 2016. Estimated direct and indirect costs to the Australian Government and businesses are $24.7 billion due to health care costs, productivity loss, reduced quality of life and premature death (Deloitte Access Economics, “Hidden Costs of Asthma”, 2015). Much of this burden comes from people with severe asthma who do not have control of their asthma symptoms despite high-dose treatment. Severe asthma is the focus of my research.

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Other

Reducing the incidence of deafness and health disadvantage in Indigenous and rural Australians through ENT Telehealth
Equipment Grant
Researchers:
Description:

Currently there is a two year wait list to see an Ear Nose & Throat (ENT) specialist in the Hunter New England district, the largest health district in NSW with one ENT specialist clinic. Lack of access to specialist health care creates a significant disparity in health outcomes for Indigenous and rural patients. Serious health complications, including deafness lead to socioeconomic disadvantage.

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Face Diagnosis / FaceMatch
Project Grant
Researchers:
Description:

Using computer vision to match the faces of children with undiagnosed intellectual disability.

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