Brain and Mental Health Research
Brain and Mental Health Research
Brain & Mental Health

NSW Health Early-Mid Career Fellowship
Fellowship
Researchers:

Dr Heidi Janssen

A new treatment to help recovery from stroke, including fatigue and quality of life
Project Grant
Description:

Funding for clinical trial coordinator for MIDAS2

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Using New Light-Based Approaches to Study Chronic Pain
Project Grant
Researchers:

Associate Professor Brett Graham, Dr Phil Jobling, Ms Kelly Smith

Description:

Changes to the nervous system during chronic pain remain poorly understood. What we do know is that nerve cells in the spinal cord play an important role in pain signalling because the spinal cord is the first site where information from our bodies is processed to ultimately shape sensory experience.

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Stroke Finder Helmet - saving time, saving brain!
Equipment Grant
Researchers:
Description:

Stroke can be devastating - often leaving a person disabled or deceased. This Stroke Finder Helmet is an innovative tool which could have enormous impact for survival and disability rates for stroke victims.

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PhD Top-Up Scholarship - Rutger de Zoete
Scholarship
Researchers:

A/Prof Suzanne Snodgrass, Mr Rutger de Zoete

Novel Mechanisms of ‘Stroke-in-Progression’: Intracranial pressure elevation and collateral blood vessel failure after minor stroke
Project Grant
Researchers:

Neil Spratt, Dr Damian McLeod

Description:

Ischaemic stroke, caused by blood clot blocking an artery to the brain, is a leading cause of death and disability. In around 10% of patients the stroke enlarges in the first 24-48 h (stroke-in-progression). Typically, these are people who arrive with mild or rapidly improving stroke symptoms, but most end up with long-term disability. There is no effective treatment, in part because for the last few decades we have been wrong about the cause for stroke progression, so have been trying to treat the wrong mechanism.

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Addiction Imaging
Project Grant
Researchers:

Adrian Dunlop, Dr Amanda Brown, Dr Chris Dayas, A/Prof Peter Stanwell.

A single centre trial evaluating microwave technology in acute stroke to differentiate haemorrhage from infarction: Stroke Finder Pilot Study
Project Grant
Researchers:
Description:

Stroke Finder Helmet Part 1 - Acute Care of Stroke Patients

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Role of infection in the development of Parkinson's Disease
Project Grant
Researchers:

Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Lin Kooi Ong

Description:

Parkinson’s disease is the second most common neurodegenerative disorder, with 6.3 million people diagnosed worldwide; 80,000 of these are Australian. This means that around one out of every 350 Australians suffers from this life changing debilitating disease. Parkinson’s disease appears more frequently in males than females. The majority of Parkinson’s disease cases are idiopathic- of unknown cause.   Parkinson’s disease is characterised by degeneration in the dopaminergic neurons in the substantia nigra (a structure in the midbrain).  The dopaminergic neurons are nerve cells that make and contain a neurotransmitter known as dopamine. Oxidative stress and neuroinflammation are thought to be involved in degeneration of the dopaminergic neurons.   

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Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Researchers:
Description:

The unmet needs of carers of stroke survivors.

 

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Growth hormone to promote brain recovery after stroke
Project Grant
Researchers:
Description:

The 470,000 Australians living with stroke are at high risk of developing cognitive deficits and vascular dementia. There are currently no generally accepted therapeutic interventions for improving cognition post-stroke.

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Jennie Thomas Medical Research Travel Grant
Travel Grant
Researchers:

Lauren Poppi

Description:

Balance is essential for every aspect of daily life and especially important for activities that people of the Hunter region are known to enjoy, including surfing, cycling, and running. A complete or partial loss of balance, or vestibular dysfunction, can be catastrophic for the individual and community.

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Sports Concussion Clinic
Project Grant
Researchers:
Jennie Thomas Travel Grant
Travel Grant
Researchers:

Joshua Atkins

Description:

Special grant for Josh Atkins to travel to France to speak at a conference and then go on to make some important collaborations in both France and UK in bioinformatics and personalised medicine.

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11th COGNO Scientific Meeting
Travel Grant
Researchers:

Catherine Hidson

Description:

Co-sponsorship for Dr Terri Armstrong to speak at 11th COGNO Scientific Meeting in Brisbane 7-9 October 2018.

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Cancer Research
Cancer Research
Cancer

Repurposing traditional chemotherapy to prime advanced melanoma for immune therapy
Project Grant
Researchers:

Dr Nikola Bowden, Dr Andre van der Westhuizen

Description:

To overcome treatment resistance in melanoma there needs to be i) decrease in the amount of disease and ii) re-establishment of tumour recognition by the immune system.

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Receptor tyrosine kinase mutations in acute myeloid leukaemia promote PP2A and p53 inhibition through the phosphorylation of SBDS
Project Grant
Description:

AML (acute myeloid leukemia) is a very aggressive form of leukemia. Tumour suppressor proteins are critically important for normal healthy cells to be protected from genetic mutations. However in AML mutations occur in the genes responsible for stem growth and cell differentiation. The growth of the blood stem cells is accelerated but their differentiation into other cells is inhibited.

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HMRI Mid-Career Clinical Research Fellowship in Brain Cancer supported by Mark Hughes Foundation
Fellowship
Researchers:

Dr Mike Fay

Description:

Understanding and overcoming treatment resistance in brain tumours

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Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Researchers:

Ms Yazmin Brown, Dr Pradeep Tanwar, Dr Susan Hua

Description:

The Role of Tumour Microenvironment in Ovarian Cancer

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Tetraspanin CD9; more than just an exosome marker - A novel biomarker to target for prostate cancer
Project Grant
Description:

Currently the major hurdle facing the successful treatment of solid cancers is the development of metastases (tumour spread), and our lack of understanding of what controls this process.

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Teaching old dogs new tricks – PARP inhibitors as treatments for childhood cancers
Project Grant
Description:

Cancer is the most common cause of childhood disease-related deaths, with leukaemia the most common childhood cancer in Australia.

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Developing new treatments for resistance in acute myeloid leukaemia
Project Grant
Researchers:
Description:

Treatment for the most common and deadly form of blood cancer (acute myeloid leukaemia) hasn’t changed in over 40 years. New treatments fail because leukaemia’s genes have a high propensity to mutate, causing rapid resistance to therapies. We have discovered that these gene mutations cause chemical-modifications to the cells defence systems. Unrestrained growth of these cancerous cells results in the production of excess reactive by-products that progressively change the cancer, making long-term treatment response and patient survival unlikely. This project will test whether targeting these chemical-modifications will be a more effective new treatment strategy.

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Neuro Oncology Networking Meeting for Nurses and Allied Health
Travel Grant
Researchers:

Marina Kastelan

Description:

Neuro Oncology is a niche area with around 500 newly diagnosed GLioma patients per year in NSW; however the care and support needs for this patient group are great, with high carer burden. 

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MHF Brain Cancer Care Coordinator
Project Grant
Researchers:

Dr Anthony Proietto

Description:

The CN2 will provide expert clinical consultancy to support high level care coordination for brain cancer patients requiring complex management.

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Targeting DNA repair for the improved treatment of blood cancers
Project Grant
Researchers:

Dr Matt Dun, Dr Nikki Verrills

Description:

By inhibiting a key player in the DNA repair pathway we could improve the effectiveness of chemotherapeutic treatments.

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Early detection and monitoring of DIPG
Project Grant
Researchers:
Description:

Half of all malignant childhood gliomas arise in the brainstem, most frequently in the ventral pons as diffuse intrinsic pontine gliomas (DIPG). The anatomical location of the tumour precludes surgical resection, leaving only radiotherapy as the established therapy. Unfortunately, radiotherapy is only temporarily beneficial, and occasionally completely fails, leaving patients without treatment option.

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Cardiovascular Research
Cardiovascular Research
Cardiovascular

Nutrition and Dietetics Research
Project Grant
Researchers:

Prof Clare Collins, Dr Lee Ashton

Description:

This project will undertake preliminary work to inform future grants and development of a personalised web-platform that supports pregnant women to optimise their dietary intakes. If a woman’s diet is compromised in pregnancy, evidence from the developmental origins of health and disease hypothesis indicates the foetus is programmed for a greater lifetime risk of chronic disease. Currently pregnant women are not routinely given advice on how to eat optimally as a way to give infants the best start to life. It is left to chance or the woman seeking information herself. This is a missed opportunity. 

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Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Researchers:
Embedding the DADEE Program in local communities: Sustainability through innovative partnerships
Project Grant
Researchers:

Prof Phil MorganProf David Lubans, Dr Myles Young, Dr Alyce Barnes, Dr Narelle Eather, Ms Emma Pollock

Description:

This three year phase of the Dads and Daughter Exercising and Empowered (DADEE) project aims to transition the DADEE program to a sustainable model embedded in the Newcastle community, capitalising on the achievements of the initial 2014-2016 grant period. 

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Characterising the role of Fibulin-3 in health and disease
Project Grant
Description:

Cardiovascular Disease is the leading cause of death worldwide and the Hunter Region has one of the highest rates of heart disease in Australia.

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The effects of dexmedetomidine on the cardiorespiratory responses to severe hypoxaemia
Project Grant
Researchers:

Anthony Quail, David Cottee

Description:

Dexmedetomidine is an intravenous sedative drug with increasing clinical use anaesthesia and intensive care. The drug acts within the central nervous system (CNS) and has potential adverse effects on the control of breathing and the circulation.

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Nutrition Connect: Online platform to link rural families to health professionals for healthy eating
Project Grant
Description:

This project will focus on providing telehealth nutrition intervention for rural parents who are concerned about their child’s weight or eating habits.

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Fibulin-3 and Cardiac Fibrosis
Project Grant
Researchers:
Description:

Heart failure is one of the most costly health problems worldwide. A hallmark of heart failure is cardiac fibrosis, an abnormal and persistent accumulation of scar tissue (mainly the extracellular matrix protein, collagen) that significantly impairs heart function.

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Fibulin-3 and Cardiac Fibrosis
Project Grant
Researchers:
Can the left atrium tell us when treatment for a patent ductus arteriosus is needed?
Project Grant
Researchers:
Description:

The left atrium (LA) is one of the four chambers of the heart. Its primary roles are to act as a holding chamber for blood returning from the lungs and to act as a pump to transport blood to the left ventricle of the heart, after which the blood flows to the body.

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ISEI Conference Travel Award
Travel Grant
Researchers:

Rebecca Haslam

Description:

To be used as a conference travel award for a late-stage PhD student or and Early Career Researcher, researching in the fields of physical activity or exercise science.

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The feasibility and preliminary efficacy of referral to exercise physiologists, psychologists, and supplementary physical behaviour change strategies for school teachers 'at risk' for Type 2 Diabetes
Project Grant
Researchers:

Professor Ronald Plotnikoff, Wendy Brown, Kerry Courneya, Ronald Sigal, Associate Professor Erica James, Professor David Lubans, Kristen Cohen

Description:

People who are 'at risk' of type 2 diabetes, or have pre diabetes, or have type 2 diabetes comprise a significant proportion of the Australian population and this health issue in increasing at a very significant rate.

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Double-blind Placebo Controlled Trial on Direct Endomyocardial Injection of Autologous bone Marrow Cells for Enhancement of Neovascularization in Patients with Ischaemic Heart Failure
Project Grant
Researchers:
Description:

Coronary artery disease (CAD) remains one of the leading causes of mortality and morbidity worldwide. Despite the optimal use of anti-anginal medications and coronary revascularization, a large number of patients with CAD suffer from severe symptoms with disabling angina and heart failure.

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Healthy Body, Healthy Mind: An exercise intervention for the treatment of youth depression
Project Grant
Description:

There has been considerable research into the use of exercise for the treatment of depression in adults, however the majority of research in adolescent major depressive disorder (MDD) over the past decade has focused on the efficacy of medications and cognitive behaviour therapy (CBT), with these methods only achieving rates of remission of 30% to 40% and high rates of relapse among those responding positively (Kennard et al., 2006).  

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Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Researchers:

Sean Hardy

Description:

The role of extracellular matrix protein 1 (ECM1) in cardiac fibrosis.

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Jennie Thomas Medical Research Travel Grant
Travel Grant
Researchers:

Sarah Kennedy

Description:

Physical inactivity has been described as a global pandemic, as it is one of the leading causes of death and disability in Australia and globally. It is directly linked to chronic conditions including obesity, Type 2 diabetes, heart disease, depression, and some cancers.

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Information Based Medicine
Information Based Medicine
Information Based Medicine

Development of a chemotherapy response/resistance test for ovarian cancer
Project Grant
Description:

Ovarian cancer is usually treated with a chemotherapy drug called cisplatin which works by damaging DNA so much that the tumour cells die. Cisplatin is used to treat a wide variety of tumours in addition to ovarian cancer including, testicular, head and neck and non-small cell lung cancer. In addition, it forms the basis of most combined treatment regimes (where 2 or more drugs are used in combination). The downside to cisplatin is that it is extremely toxic and although some patients benefit substantially from treatment, a large proportion suffer the toxic side effects without any therapeutic benefit. We are aiming to develop a personal test to determine if cisplatin is likely to be effective for an individual’s ovarian cancer, so that the toxic side effects can be avoided if the drug is not going to work.

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Small p53 isoforms, BIG implications for treatment response in breast cancer
Project Grant
Researchers:
Description:

Breast cancer is the most common cancer in women, with 1 in 9 women diagnosed in their lifetime

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Pregnancy & Reproduction Research
Pregnancy & Reproduction Research
Pregnancy & Reproduction

Improving glucose control and health outcomes for people with diabetes
Project Grant
Researchers:

Conjoint A/Prof Bruce King, Dr Carmel Smart

Description:

Type 1 diabetes (T1D) is the fastest growing chronic disease affecting Australian children. T1D is a lifelong condition where the body is not able to produce insulin which controls blood glucose. People with T1D must follow a strict daily regime of blood glucose testing, insulin administration and careful dietary management to control their blood glucose levels. Good blood glucose control is critically important in preventing life- threatening complications of diabetes.

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Establishing a nanoparticle development facility at HMRI
Fellowship
Researchers:
Description:

This proposal seeks funding to establish a Targeted Nanoparticle Development Facility within the Hunter Medical Research Institute. We also seek funding for a post-doctoral scientist who will use the technology to develop novel diagnostics that will identify cancer metastases from thyroid and ovarian cancers, locate other endocrine cancers and importantly develop new ways of treating ovarian and thyroid cancer through improved delivery of existing chemotherapy drugs.

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Gomeroi gaaynggal - Safety and Wellbeing
Project Grant
Researchers:
Description:

The Provider will implement the ‘Gomeroi Gayaanggal’ Project to provide a holistic approach to social and emotional wellbeing within the Indigenous communities of Tamworth and Walgett, and will add Taree and Forster in Stage 2. 

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Is placental aging the key to understanding, predicting and preventing stillbirth?
Fellowship
Researchers:
Description:

Globally, nearly 1% of all pregnancies end in stillbirth (3 million each year). The magnitude and gravity of stillbirth is such that in 2011 an entire Lancet series was devoted to it and urged a strong call to action, concluding that greater knowledge of causes is a key health priority. In Australia, stillbirth accounts for around 70% of all perinatal deaths (7 deaths per day) and is nearly 40 times more common than Sudden Infant Death Syndrome. Existing knowledge has had no impact on reducing the stillbirth rate, and a 2013 BMJ review of the UK data on stillbirth concluded ""preventive strategies need to focus on improving antenatal detection."

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Australian Artificial Pancreas Program
Project Grant
Researchers:

Bruce King, Graham Goodwin

Gomeroi gaaynggal Community ArtsHealth
Project Grant
Researchers:
Description:

Funding to support the Gomeroi gaaynggal Community ArtsHealth running in Tamworth - covers art consumables which brings participants into the centre to participate in health screening and research being conducted.

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The prediction and prevention of hypoglycaemia using insulin suspension in a randomised controlled trial (PLGM study)
Project Grant
Researchers:

A/Prof Bruce King

Helping to Close the Gap by determining the prevalence of iodine deficiency and related thyroid and goitre health problems
Project Grant
Researchers:

Patrick Oakley

Description:

The New South Wales tablelands are a known region to have low environmental iodine in soil. This is similar to other regions around the world such as the Himalayas and Papua New Guinea. This is known to impact the food grown locally. The introduction of iodised salt into diets has assisted in reducing the impact. However, modern diets with a reliance on processed foods that are not required to use iodised salt, has left "modern diets" deficient in iodine.

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Stillbirth video production - travel grant
Travel Grant
Researchers:
Description:

Travel funding to Wellington NZ to learn 3D animation 13/4/2018-25/4/2018

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Haggarty Foundation HMRI Research Fellowship in Stillbirth
Fellowship

Public Health Research
Public Health Research
Public Health

Reducing the impact of back pain in miners
Project Grant
Description:

Can miners at risk of long-term low back pain be identified and provided with a low back pain prevention intervention to prevent the development of persistant pain co-existing lifestyle health risks?

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Improving uptake of colorectal cancer screening among primary care attendees
Scholarship
Researchers:
Description:

Despite innovative programs to increase colorectal cancer (CRC) screening amongst people >50 years of age, such the National Bowel Cancer Screening Program (NBCSP), current screening rates are low.

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Award for Early Career Research - Serene Yoong
HMRI Award for Early Career Research
Researchers:
Award for Research Excellence - Jennifer Martin
HMRI Award for Research Excellence
Jennie Thomas Medical Research Travel Grant
Travel Grant
Researchers:

Kathryn Reilly

Description:

I am an Early Career Researcher with a passion for improving the health of children, specifically through nutrition school-based policies and practices. My PhD project focused on the development of a scalable policy implementation support program for a state-based school healthy eating strategy.

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Viruses, Infections / Immunity, Vaccines & Asthma
Viruses, Infections / Immunity, Vaccines & Asthma
Viruses, Infections / Immunity, Vaccines & Asthma

Mary Sawyer PostGraduate Scholarship in Cancer Research
Scholarship
Researchers:

Ms Georgia Carroll, Dr Simon Keely, Dr Peter Pockney

Description:

Colorectal cancer (CRC) is the commonest cancer that affects both men and women in Australia. Approximately one third of patients diagnosed with the disease die from it within five years of diagnosis. Most of these deaths occur from metastatic disease. Many of these cancers develop in patients who had no apparent metastatic disease when they were first treated with what is intended to be curative resection.

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Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Researchers:

Ms Bridie Goggins, Dr Simon Keely, Prof Darryl Knight, Dr Jay Horvat

Investigation of the role of mechanical forces in respiratory disease
Project Grant
Investigating the role of microbiomes in COPD
Project Grant
Researchers:
Description:

Smoking leads to lung inflammation that causes emphysema - a major health problem in Australia. Emphysema progressively declines even if smoking stops and there are no treatments. Recently changes in gut microbes have been linked to inducing or protecting against inflammation in the gut and lung. Thus we may be able to control inflammation by modifying these gut microbiomes. We may be able to ingest specific microbes or use specific antibiotics or other factors as new treatments for emphysema.

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Award for Mid Career Research - Lisa Wood
HMRI Award for Mid Career Research
Researchers:
Patient Reported Outcome Measure in Severe Asthma (PROMISe): Measuring Severe Asthma’s Impact on Health Status
Project Grant
Description:

Asthma is a common condition that causes tightness in the chest, coughing and wheeze and makes it difficult to breath. Around 10.2% of the Australian population (approximately 2.3 million people) have asthma, it is a major health problem here in Australia and worldwide.

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Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Researchers:

Vrushali Chimankar

Description:

Investigating the genetics of the development of lung cancer.

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The role of apical mechanical shear stress on epithelial cell function in asthma
Project Grant
Researchers:
Description:

Bronchoconstriction is a cardinal feature of asthma, generating mechanical stresses within the airways including cell compression and increased shear stress due to increased air-flow.

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Jennie Thomas Medical Research Travel Grant
Travel Grant
Researchers:

Sarah Hiles

Description:

Asthma is a common and often disabling chronic disease that makes breathing difficult. Approximately 3 million Australians have asthma – 10% of the population. Asthma causes significant lifetime disability, has a high disease burden, and caused 455 deaths in Australia in 2016. Estimated direct and indirect costs to the Australian Government and businesses are $24.7 billion due to health care costs, productivity loss, reduced quality of life and premature death (Deloitte Access Economics, “Hidden Costs of Asthma”, 2015). Much of this burden comes from people with severe asthma who do not have control of their asthma symptoms despite high-dose treatment. Severe asthma is the focus of my research.

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Understanding immune and inflammatory mechanisms of disease in the urinary system
Project Grant
Researchers:
Description:

Kidney stones affect approximately 9% of the population, with rates increasing globally. Whilst the surgical techniques used to remove obstructive stones have improved, few if any advances have been made to prevent stone recurrence. Stones are a significant risk factor for the development of chronic kidney disease, which currently affects 2 million Australians.

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Other

Reducing the incidence of deafness and health disadvantage in Indigenous and rural Australians through ENT Telehealth
Equipment Grant
Researchers:
Description:

Currently there is a two year wait list to see an Ear Nose & Throat (ENT) specialist in the Hunter New England district, the largest health district in NSW with one ENT specialist clinic. Lack of access to specialist health care creates a significant disparity in health outcomes for Indigenous and rural patients. Serious health complications, including deafness lead to socioeconomic disadvantage.

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Advanced Out of Hospital Care
Project Grant
Researchers:
Description:

Develop, implement and evaluate an evidence based education program for paramedics, related telehealth technologies and a model of care which enables "Advanced Out of Hospital Care".

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Face Diagnosis / FaceMatch
Project Grant
Researchers:
Description:

Using computer vision to match the faces of children with undiagnosed intellectual disability.

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