New treatment options are very effective in reducing inflammation in MS and significantly reducing relapse rate. They are less effective in stopping progression of the disease. This project aims to highlight the importance of proton magnetic resonance spectroscopy, and specifically the role that GABA, a major inhibitory transmitter, plays in MS progression. Monitoring GABA in vivo, in a timely manner, has the potential of evaluating the effectiveness of tresatment in MS patients.
Magnetic resonance imaging is not only important in the diagnosis of multiple sclerosis but also to monitor therapy.