Conjoint Professor Chris Levi

Professor Chris Levi
Research Program:
Research Topics:
Project Grant
2016 Project Grant
Project Grant
2014 Project Grant
Project Grant
2013 Project Grant
Fellowship
2013 Fellowship
Project Grant
2013 Project Grant
Project Grant
2013 Project Grant
Project Grant
2013 Project Grant
Project Grant
2013 Project Grant
Project Grant
2012 Project Grant
Project Grant
2011 Project Grant
Scholarship
2011 Scholarship
Project Grant
2010 Project Grant
Project Grant
2010 Project Grant
Scholarship
2010 Scholarship
Project Grant
2009 Project Grant
HMRI Award for Research Excellence
2009 HMRI Award for Research Excellence
Project Grant
2008 Project Grant
Fellowship
2007 Fellowship
Project Grant
2007 Project Grant
Project Grant
2007 Project Grant
Project Grant
2006 Project Grant
Project Grant
2004 Project Grant
Project Grant
2003 Project Grant
Project Grant
2003 Project Grant
Fellowship
2000 Fellowship
Project Grant
1998 Project Grant

What are your research interests?

  • Acute stroke clinical trials
  • Acute Stroke Imaging with CT, MRI and Doppler
  • Stroke Epidemiology and Genetic Epidemiology
  • Systems and Implementation Research 

The John Hunter Hospital Stroke Unit and Acute Stroke Research Group were founded in 1999 and the group is now nationally and internationally recognised as leaders in the development of new strategies in acute stroke imaging and therapies. Activities span from experimental laboratory research through to community-based studies and health systems implementation. The generation of new knowledge and its translation to improve health care outcomes for stroke sufferers is being realised with the Hunter now being one of the international leading sites for implementation of clot busting therapies for stroke. 

Why did you get into research?

When I began my clinical career in neurology there were no effective acute stroke therapies. The pressing need to be able to help acute stroke sufferers drove my interest in both the discovery of new treatments and the translation of those treatments into the real world of clinical care. 

What would be the ultimate goal for your research?

To provide the best, most advanced research based clinical care for acute stroke sufferers and to discover and implement new ways of preventing stroke. 

Biography

Conjoint Professor Chris Levi is the Director of Clinical Research and Translation - Research Innovation and Partnerships  and Co-Director of Acute Stroke Services at John Hunter Hospital, Hunter New England Local Health District. He has a clinical and research passion for improving outcomes of patients who are affected by stroke and Transient Ischemic Attacks (TIA). 

Stroke is the leading cause of long term adult disability and is the second leading cause of death, both in Australia and globally. Professor Levi is part of a world-recognised team who are working to transform the clinical treatment of stroke and give the 50,000 Australians who are affected each year a better recovery. 

Since arriving back in Newcastle in 1999 to establish the John Hunter Hospital Stroke Unit and Research Group, Professor Levi has made a number of ground-breaking discoveries and led prestigious clinical trials and studies. One of the major advances in recent years is the trial of the new clot-busting drug for treatment of stroke called Tenecteplase, co-led by Professor Chris Levi and Professor Mark Parsons.  

Professor Levi is also researching a number of other aspects of stroke to try and improve outcomes for patients. He is investigating genetic factors that may predispose someone to having a stroke so that it can hopefully be prevented and treatment can be tailored accordingly. 

Optimising the triage protocol for stroke patients so that they receive the right care straight away is another important aspect of research and evidence based practice for Professor Levi and his team. Many treatments for stroke are highly dependent on the time at which they are administered after the onset of stroke and therefore an effective triage strategy could make all the different for a patient. Thanks to initiatives such as this, Newcastle is far above the national average in treatment times for stroke patients, raising the bar from approximately 5 per cent of patients around the country that are treated in time to receive clot-busting drugs to around 20-30 per cent in Newcastle.

Professor Levi is a highly respected clinical researcher with >250 peer-reviewed publications and over 160 invited talks and sessions chaired at major national and international meetings, as well as extensive experience serving on steering committees of major clinical trials. His strong international reputation is supported by publications in preeminent journals such as Nature Genetics, New England Journal of Medicine and The Lancet.

Specialised/Technical Skills 

  • Clinical research and clinical trails
  • Observational epidemiology
  • Case control studies and cohort studies
  • Prevalence and incident studies
  • Interventional clinical trials
  • Antithrombotic therapy
  • Stroke prevention and  acute stroke therapy trials
  • Health services work
  • Cluster randomised trials
  • Health services interventions and health service redesign
  • Brain imaging research and Neurovascular ultrasound
  • Transcranial Doppler embolus protection
  • Multi-modal CT imaging, MRI brain imaging & stroke imaging

Affiliations

2016

Stroke Helmet
Project Grant
Researchers:

2014

Neuroimaging Biomarkers of Recovery: Longitudinal Imaging Study in the Rehabilitation Phase post-Acute Ischemic Stroke (NEUROLISS)
Project Grant
Description:

The proposed project is highly significant because it will, for the first time, to accurately map the changes that occur in the brain following stoke and identify patters for good clinical outcomes.

more

2013

Biological characterisation of genetic associations for large artery atherosclerotic stroke
Project Grant
Researchers:

Dr Elizabeth Holliday, Rodney Scott, Christopher Levi, John Attia 

Description:

Genetic risk factors, gene expression and ischaemic stroke

more
Mapping whole-brain metabolic networks
Project Grant
Researchers:

Dr Renate Thienel, Frini Karayanidis, Juanita Todd, Peter Stanwell, Mark Parsons, Chris Levi

Description:

Mapping networks in the brain

more
An Evaluation of Transitional Care for Stroke Patients
Project Grant
Researchers:

Dr Ashley Kable, Amanda Baker, Dimity Pond, Alyna Turner, Chris Levi, Carolyn Hullick 

Description:

Evaluating transitional care - When a stoke patient goes home

more
The genetic determinants of brain haemorrhage associated with stroke thrombolysis
Project Grant
Researchers:

Professor Christopher Levi, J. Sturmm, Mark Parsons, Neil Spratt, A. Loiselle, B. O'Brien, V. Zenteno, L.Holliday, Rodney Scott, J. Maguire 

Description:

Stroke is the leading cause of long-term disability in Australia and the second leading cause of death.

more
Greater Charitable Foundation Fellows in Stroke Research
Fellowship
Description:

This funding was provided to fund the vanguard phase of two clinical trials in stroke:

more
Quota International funding
Project Grant

2012

Greater Charitable Foundation Fellows in Stroke Research
Project Grant

2011

Experimental brain imaging to investigate novel protective mechanisms of short duration body cooling after stroke - Dalara Foundation Stroke Research Project Grant
Project Grant
Relationships between white matter lesions and cognitive and motor functioning in patients with minor ischaemic stroke: A structural and functional brain imaging study - RhD 2yr
Scholarship
Researchers:

Dr Frini Karayanidis, Mark Parsons, Chris Levi, Grant Bateman, Patricia Michie, Peter Schofield & Todd Jolly
 

2010

Relationships between white matter lesions and cognitive and motor functioning in patients with minor ischaemic stroke: A structural and functional brain imaging study - RhD 2yr
Scholarship
Researchers:

Dr Frini KarayanidisMark Parsons, Chris Levi, Grant Bateman, Patricia Michie, Peter Schofield & Todd Jolly
 

A structural and functional brain imaging study of how white matter lesions in patients with minor ischaemic stroke affect cognitive and motor control processes
Project Grant
Researchers:

Dr Frini Karayanidis, Mark Parsons, Patricia Michie, Christopher Levi, Sharna Jamadar, Matthew Hughes, Peter Schofield, Dr Grant Bateman

Vascular Ischemia Study
Project Grant
Researchers:

2009

Award for Research Excellence - Chris Levi
HMRI Award for Research Excellence
Towards better early imaging in stroke: use of an experimental model to investigate CT brain perfusion
Project Grant

2008

A randomised controlled trail of mild hypothermia in acute ischaemic stroke
Project Grant
Researchers:

2007

A functional MRI and tractography study of the effect of early upper limb therapy on brain plasticity after stroke
Project Grant
Researchers:

Dr Timothy Budd, Dr Mark Parsons, Dr Chris Levi
 

A functional MRI study of Upper limb therapy in acute stroke
Project Grant
Researchers:

Dr Mark Parsons, Dr Bill Budd, Dr Chris Levi
 

Keeping Brain Cells alive in Stroke Treatment
Fellowship
Researchers:

Dr Christopher Levi, Professor Mike Calford, Dr Mark Parsons
 

2006

The visual form and motion test as a measure of post-cardiac surgery cognitive impartment
Project Grant
Researchers:

Dr Neva Bull, Associate Professor M Hunter, Chris Levi
 

2004

Examine Genetic Factors that could influence blood clot formation and Breakdown
Project Grant
Researchers:

2003

Novel genetic and environmental risk factors in thrombosis
Project Grant
Researchers:
Intra Mycardialial injection of autogous Bone Marrow cells in patients with end stage ischaemic heart disease.
Project Grant
Researchers:

2000

"Influence of glycaemic control on outcome after acute ischaemic stoke in diabetic patients. Later known as 03-22"
Fellowship
Researchers:

Dr Christopher Levi, Dr Julia Lowe
 

1998

Stroke Research - Dextran in Carotid Endarterectomy
Project Grant
Researchers: