Associate Professor Jay Horvat

Associate Professor Jay Horvat
Equipment Grant
2017 Equipment Grant
Scholarship
2016 Scholarship
Scholarship
2015 Scholarship
Project Grant
2014 Project Grant
Project Grant
2013 Project Grant
Project Grant
2011 Project Grant
Scholarship
2011 Scholarship
Project Grant
2010 Project Grant
Project Grant
2009 Project Grant

What are your research interests?

  • Role and therapeutic targeting of dysregulated iron handling in infection and inflammatory diseases of the lung
  • Role and therapeutic manipulation of sex hormones in influencing biological processes that underpin inflammatory conditions such as asthma and pelvic pain
  • Understanding the effects of different occupational and environment particulate matter exposures on respiratory health outcomes in order to identify more effective prevention and treatment strategies

Why did you get into research?

From an early age I have always been one of those people that needs to know how and why things work. When I enrolled in a Bachelor of Biomedical Science at the University of Newcastle I was blown away by how amazing the biology of the human body is and knew straight away that a career in medical research and teaching was perfect for me. I quickly became fascinated in immunology and microbiology and have focused my work on understanding how infections and immune responses interact with and/or disrupt biological processes in the body in order to promote a number of inflammatory diseases for which we currently have poor treatment options.

What would be the ultimate goal for your research?

My overarching goal is to use knowledge gained from my research to identify new, more effective therapies or management strategies for diseases such as asthma, emphysema, influenza, multiple sclerosis and pelvic inflammatory disease.

I also take great pride through both my research and teaching in fostering the next generation of medical researchers. We have a very young group of brilliant and enthusiastic scientists that I would love to see go on to be successful researchers making waves on a national and international scale.

Biography

Jay Horvat is an Associate Professor in Immunology and Microbiology with a keen interest in the investigation and therapeutic targeting of infection and inflammation-induced diseases of the central nervous system and reproductive and gastrointestinal tracts. His major focus is on asthma and respiratory diseases.

Inflammation plays a key role in asthma and other respiratory diseases such as idiopathic pulmonary fibrosis and emphysema/COPD. Drugs that directly target inflammation are usually touted as the answer to these diseases. Jay is working with a range of research teams to better understand fundamental biological processes that influence inflammatory cells and responses in order to discover new, cost effective methods for controlling inflammation in these diseases. Two of the major areas of research focus on the relationship between iron regulation and immune responses in the lungs and the interplay between sex hormones and obesity/diet in inflammatory cell responses.

Specialised/Technical Skills

I have extensive experience in the development and analysis of highly representative clinical and experimental models of a number of infection and inflammation-induced diseases of different organ systems. I not only utilise the models that I develop to help discover new pathological processes that underpin disease but also test novel therapies that target these processes for the improved treatment of disease.

Affiliations

Downloads

ABC Newcastle interview with Kia Handley - 10 December 2019

2017

Flexivent FX base unit controller and software
Equipment Grant
Researchers:

Dr Jay Horvat, Dr Chantal Donovan, Dr Richard Kim, Dr Shakti Shulka, Dr Prema Nair, Dr Md Atiqur Rahman

Description:

The Baseunit controller extension is required to ventilate the models whilst on the machine and run the new lung function ""maneuvers"" that are required to gather the PFT/FEV data.

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2016

Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
Scholarship
Description:

Inflammatory bowel disease (IBD) is characterised by chronic, immune-mediated inflammation of the gastrointestinal tract (GIT) and encompasses a number of conditions including ulcerative colitis (UC) and Crohn’s disease (CD). Due to the seriously debilitating nature of IBD, novel therapeutics to improve IBD patient quality of life is a significant healthcare need.

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2015

Greaves Family Postgraduate Scholarship in Medical Research
Scholarship
Researchers:

Mr James Pinkerton, Jay Horvat, Phil Hansbro

Description:

The Greaves Family Postgraduate Scholarship in Medical Research will allow James Pinkerton to complete his PhD studies to understand the mechanisms that underpin steroid-resistant asthma.

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2014

Investigation of the progression of Alzheimer’s Disease: Identification of potential drivers of disease
Project Grant
Researchers:
Description:

Our research group is investigating the link between smoking and infection in disease progression in an experimental model of Alzheimer’s disease.

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2013

The role of the microbiome in the development of food allergy
Project Grant
Description:

The role of the microbiome (gut bacteria) in the development of food allergy

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2011

Mechanisms of predisposition to secondary bacterial pneumonia - Greaves Family Research Higher Degree Support Grant
Scholarship
Researchers:
Elucidating the mechanisms of steroid-resistant asthma.
Project Grant

2010

Antioxidant therapies for suppressing infection-induced asthma in children
Project Grant

2009

PULSE Education Prize
Project Grant
Researchers: