Dr Lei Jin

Research Program:
Project Grant
2017 Project Grant
Project Grant
2016 Project Grant
Project Grant
2015 Project Grant
Project Grant
2013 Project Grant

What are your research interests?

  • To overcome the resistance of melanomas to chemotherapy and targeted therapy
  • To identify long non-coding RNAs as biomarkers in melanoma to chemotherapy, targeted therapy and immunotherapy
  • To investigate the signalling pathways responsible for melanoma tumorigenesis 

Why did you get into research? 

Australia has the highest incidence of melanoma in the world, which has a disproportionately heavy impact on the productive years of the lives of young Australians. Curative treatment of metastatic melanoma still remains an unmet health problem. Investigation of genes and signalling pathways that are deregulated in melanoma is a high priority for identification of novel therapeutic targets. 

What would be the ultimate goal for your research?

My ongoing research objective is overcoming resistance of melanoma to chemotherapy and targeted therapy. The outcome of the study will reveal mechanisms of melanoma drug resistance and result in more accurate and cost effective approaches for the treatment of melanoma patients.

Biography

Dr Jin is currently leading the melanoma research laboratory investigating cell death, a group that comprises two visiting academics, four PhD students and one research assistant. In the past five years, he has published 24 research articles in high impact journals including Nature Communications, PNAS, Cancer Research, Autophagy, Oncogene, Cell Death and Differentiation and Stem cells.  

Since Dr Jin joined HMRI in 2013 he has attracted an NHMRC project grant, two HMRI project grants and a Faculty of Health and Medicine Strategic Pilot Grant. In addition, as a Chief Investigator, Dr Jin has received a number of competitive grants from other sources including the National Natural Science Fund of China and Faculty of Health and Medicine. Particularly, he was awarded Hunter Translational Cancer Research Unit Fellowship in 2013 and a highly competitive Cancer Institute NSW Early Career Fellowship in 2014. 

Dr Jin has served as a reviewer to assess grant applications for national and international funding bodies including NHMRC and the National Natural Science Fund of China. He also has been invited to review manuscripts for a number of journals including Cancer Research, Oncogene, Neoplasia, Molecular Cancer Therapeutics, Molecular Cancer Research, and PLOS One. In addition to HMRI, Dr Jin actively participates in activities of academic organisations, including American Association for Cancer Research (AACR), the Australia and New Zealand Melanoma Trials Group, Melanoma Institute Australia, and Melanoma Tumour Group of the Hunter New England Area Health.

He has ongoing collaborations with a large number of researchers locally, nationally, and internationally.  In particular, he has established productive collaborations with researchers in China, including Professor Zhiyin Song of Wuhan University and Professors Mian Wu and Yide Mei of the University of Science and Technology of China. He also provides a consultancy service to other researchers in Newcastle on molecular biology and biochemistry techniques on a daily basis.

Dr Jin was among the first to show that p53 (a common tumour suppressor gene) played a pro-survival role in melanoma cells upon endoplasmic reticular stress (a type of cellular 'stress' that occurs in many types of cancer). More recently, Dr Jin has become a leading figure in investigation of the roles of microRNAs (small molecules that alter how genes are expressed) and Receptor-Interacting Protein Kinases in regulation of melanoma cell survival and proliferation.

Jin is actively engaged in communications with the general public, in particular, melanoma patients and their friends and relatives.  He regularly presents the work in lay language to various community groups, such as members of Newcastle Melanoma Foundation and Melanoma Institute Australia.

Future Focus

To develop innovative approaches to improve therapeutic efficacy in the treatment of melanoma.

Specialised/Technical Skills 

  • Cancer biology
  • Cell death assays
  • Signal transduction

Affiliations 

2017

Oncogenic upregulation of the long noncoding RNA MAFG-AS1
Project Grant
Description:

It has become apparent over the last decade that a class of molecules called long noncoding RNAs (lncRNA), which were originally thought to be ‘junk’ in mammalian cells, play a major role in controlling gene expression and disease. 

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2016

Improving the treatment benefit of immunotherapy in cancer
Project Grant
Description:

Cancer immunotherapy is a therapeutic strategy that harnesses cancer patients own immune system to specifically target cancer cells. A new class of newly developed drugs in cancer immunotherapy (called immune checkpoint inhibitors) can cause long lasting regression of tumors and prevent relapse but only a small number of patients currently benefit from these drugs.

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2015

A novel approach to destruct melanoma
Project Grant
Description:

Australia has the highest incidence of melanoma in the world and kills more young Australians aged 20–34 years old than any other single cancer. 

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2013

RIPK1 as a novel therapeutic target in melanoma
Project Grant
Researchers:
Description:

A new target for melanoma treatment 

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