Emeritus Professor Peter Dunkley

Project Grant
2018 Project Grant
Project Grant
2017 Project Grant
Project Grant
2016 Project Grant
Project Grant
2015 Project Grant
Project Grant
2014 Project Grant
Project Grant
2010 Project Grant
Project Grant
2006 Project Grant
Equipment Grant
2006 Equipment Grant
HMRI Award for Research Excellence
2002 HMRI Award for Research Excellence
Project Grant
2000 Project Grant

What are your research interests?

My main research interest is in understanding the causes of Parkinson's disease. We have developed a model in which activation of the peripheral immune system induces a loss of specific nerves, in a manner similar to that which occurs in Parkinson's disease. We are interested in how immune system activation causes the loss of dopaminergic (dopamine releasing) nerves.

Another interest is the role of catecholamines (naturally occurring amines that function as neurotransmitters and hormones within the body, such as adrenaline and dopamine) in response to stress. Stress induces the activation of specific nerves and this can be monitored by determining the activation of tyrosine hydroxylase - the rate limiting enzyme in catecholamine synthesis.

Why did you get into research?

I find understanding the way in which the brain operates at a molecular level fascinating. As it is the basis of all neurological and psychiatric disorders, it is clearly important.

What would be the ultimate goal for your research?

In the near future, I will be focusing on our recently developed model for Parkinson's disease.There will be no end point to understanding brain function in my lifetime. However, I would like to know how changes in signal transduction in catecholaminergic cells controls the activity of these cells in response to a range of stressors. In particular I would like to know exactly how immune activation can lead to Parkinson's disease.

Brief Profile

Professor Dunkley's research has always focused on signal transduction in neuronal and endocrine tissues (tissues that relsease hormones) and especially on protein phosphorylation (a type of modification that can activate or deactivate a protein). 

His interests have moved from a marker called myelin basic protein that is able to induce models of multiple sclerosis, to synapsin I that controls neurotransmitter release, to tyrosine hydroxylase that controls catecholamine synthesis. 

Professor Dunkley's focus recently has been on mechanisms of synthesis and secretion of the catecholamines (dopamine, noradrenaline and adrenaline) and the consequences of changes in dopamine synthesis in Parkinson’s disease. 

Specialised / Technical Skills

Professor Dunkley has skills in using laboratory models for neurological diseases to test molecular hypotheses, especially those involving signal transduction pathways involving protein phosphorylation.

Affiliations

2018

Role of infection in the development of Parkinson's Disease
Project Grant
Researchers:

Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Lin Kooi Ong

Description:

Parkinson’s disease is the second most common neurodegenerative disorder, with 6.3 million people diagnosed worldwide; 80,000 of these are Australian. This means that around one out of every 350 Australians suffers from this life changing debilitating disease. Parkinson’s disease appears more frequently in males than females. The majority of Parkinson’s disease cases are idiopathic- of unknown cause.   Parkinson’s disease is characterised by degeneration in the dopaminergic neurons in the substantia nigra (a structure in the midbrain).  The dopaminergic neurons are nerve cells that make and contain a neurotransmitter known as dopamine. Oxidative stress and neuroinflammation are thought to be involved in degeneration of the dopaminergic neurons.   

more

2017

Role of infection in the development of Parkinson's Disease
Project Grant
Researchers:

Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Lin Kooi Ong

Description:

Parkinson’s disease is the second most common neurodegenerative disorder, with 6.3 million people diagnosed worldwide; 80,000 of these are Australian. This means that around one out of every 350 Australians suffers from this life changing debilitating disease. Parkinson’s disease appears more frequently in males than females. The majority of Parkinson’s disease cases are idiopathic- of unknown cause.   Parkinson’s disease is characterised by degeneration in the dopaminergic neurons in the substantia nigra (a structure in the midbrain).  The dopaminergic neurons are nerve cells that make and contain a neurotransmitter known as dopamine. Oxidative stress and neuroinflammation are thought to be involved in degeneration of the dopaminergic neurons.

more

2016

Role of Infection in the Development of Parkinson's Disease
Project Grant
Researchers:

Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Lin Kooi Ong

Description:

Parkinson’s disease is the second most common neurodegenerative disorder, with 6.3 million people diagnosed worldwide; 80,000 of these are Australian. This means that around one out of every 350 Australians suffers from this life changing debilitating disease. Parkinson’s disease appears more frequently in males than females. The majority of Parkinson’s disease cases are idiopathic- of unknown cause.   Parkinson’s disease is characterised by degeneration in the dopaminergic neurons in the substantia nigra (a structure in the midbrain).  The dopaminergic neurons are nerve cells that make and contain a neurotransmitter known as dopamine. Oxidative stress and neuroinflammation are thought to be involved in degeneration of the dopaminergic neurons.   

more

2015

Role of infection in the development of Parkinson's Disease
Project Grant
Researchers:

Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Lin Kooi Ong

Description:

Parkinson’s disease is the second most common neurodegenerative disorder, with 6.3 million people diagnosed worldwide; 80,000 of these are Australian. This means that around one out of every 350 Australians suffers from this life changing debilitating disease. Parkinson’s disease appears more frequently in males than females. The majority of Parkinson’s disease cases are idiopathic- of unknown cause.   Parkinson’s disease is characterised by degeneration in the dopaminergic neurons in the substantia nigra (a structure in the midbrain).  The dopaminergic neurons are nerve cells that make and contain a neurotransmitter known as dopamine. Oxidative stress and neuroinflammation are thought to be involved in degeneration of the dopaminergic neurons.   

more

2014

Role of infection in the development of Parkinson's Disease
Project Grant
Researchers:

Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Lin Kooi Ong

Description:

Parkinson’s disease is the second most common neurodegenerative disorder, with 6.3 million people diagnosed worldwide; 80,000 of these are Australian. This means that around one out of every 350 Australians suffers from this life changing debilitating disease. Parkinson’s disease appears more frequently in males than females. The majority of Parkinson’s disease cases are idiopathic- of unknown cause.   Parkinson’s disease is characterised by degeneration in the dopaminergic neurons in the substantia nigra (a structure in the midbrain).  The dopaminergic neurons are nerve cells that make and contain a neurotransmitter known as dopamine. Oxidative stress and neuroinflammation are thought to be involved in degeneration of the dopaminergic neurons.   

more

2010

The central neural pathway that controls the release of catecholamines from the adrenal medulla: it is impaired in hypertension?
Project Grant
Researchers:

Professor Peter Dunkley, Ann Goodchild 

2006

Bio-Rad Mini-PROTEAN 3 Electrophoresis system
Equipment Grant
Researchers:

Professor Leonie Ashman, Dr P Dickson, Professor Peter Dunkley, Professor J Rostas, Dr J Scott, Associate Professor A Sim, Dr N Verrills

Control of Dopamine synthesis and Parkinsons' Disease
Project Grant
Researchers:

Dr Phillip Dickson, Professor Peter Dunkley
 

2002

Award for Research Excellence - Peter Dunkley
HMRI Award for Research Excellence

2000

The effects of lead on cells.
Project Grant
Researchers:

Professor Peter Dunkley, Dr Perry Hartfeilf