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Mr Jakobi Stegh

Mr Jakobi Stegh

Co‑authored a European Journal of Medicinal Chemistry paper simplifying indole‑based dynamin inhibitors to a pyrrole scaffold, retaining CME inhibition with improved solubility and drug‑likeness
Co‑authored a European Journal of Medicinal Chemistry paper simplifying indole‑based dynamin inhibitors to a pyrrole scaffold, retaining CME inhibition with improved solubility and drug‑likeness.
Published in ACS ES&T Water (2023) on in‑situ sequestration of multicomponent PFAS in groundwater using injectable adsorbent suspensions, crcCARE‑funded research.

Jakobi Stegh is the Co-Founder and Director of Mechanistic Health, where he and his team develop scientific reference tools for use in academic and clinical settings. Their flagship product, eDIP (the Electronic Drug Interaction Platform), translates complex drug interaction data and receptor mechanisms into accessible resources for clinicians, researchers, carers, and consumers, bridging the gap between primary literature and the people who need it most.

His research interests lie in organic chemistry, natural product synthesis, and pharmacology. He is passionate about taking complex organic molecules inspired by nature and applying them to the design of precise pharmaceutical agents. With a focus on biosynthetic pathways and drug interactions within the human body, he aims to contribute to meaningful advancements in synthetic chemistry.